Accelerated induction of etorphine immobilization in blue wildebeest (Connochaetes taurinus) through the addition of hyaluronidase

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dc.contributor.author Dittberner, Mark
dc.contributor.author Venter, Leon
dc.contributor.author Naidoo, Vinny
dc.date.accessioned 2016-02-12T07:52:48Z
dc.date.issued 2015-03
dc.description.abstract OBJECTIVE : To study the effects of the addition of hyaluronidase (HA) to an etorphine/azaperone drug combination on induction times of immobilization. STUDY DESIGN : Experimental part-randomized 'blinded' cross-over study. ANIMALS : Eight wild managed blue wildebeest (Connochaetes taurinus). METHODS : Animals were immobilized, on separate occasions separated by two weeks, with one of four treatments. Treatments were; 'Control drugs (CD), etorphine 0.01 mg kg(-1) + azaperone at 0.1 mg kg(-1) ; treatment 1 CD + 5000IU HA; treatment 2 CD + 7500 IU HA; and treatment 3 etorphine 0.007 mg kg(-1) + azaperone at 0.07 mg kg(-1) + 7500 IU HA. Times to first effect and to immobilization (from darting to possible to approach and blindfold) were measured. anova was used to compare treatments. Results are given in means ± SD (range). RESULTS : For control, and treatments 1-3 respectively, times (in minutes) to first effect were 1.58 ± 0.42 (1.02-2.10), 1.64 ± 0.42 (0.95-2.17), 1.12 ± 0.24 (0.80-1.48) and 1.60 ± 0.21 (1.13-1.88) and to immobilization were 5.38 ± 1.53 (3.82-8.07), 3.80 ± 1.14 (2.02-5.50), 3.51 ± 1.08 (2.28-5.52) and 4.46 ± 0.67 (3.30-5.40). Compared to control, time to first effect for treatment 2 was significantly shorter. Time to immobilization was significantly quicker in all three treatments containing HA than that for control. CONCLUSION AND CLINICAL RELEVANCE : Hyaluronidase can reduce the time to immobilization when used in the immobilizing dart, and might be usefully incorporated into etorphine combinations for darting wildlife. en_ZA
dc.description.embargo 2016-03-31
dc.description.librarian hb2015 en_ZA
dc.description.sponsorship University of Pretoria and the South African Veterinary Foundation. en_ZA
dc.description.uri http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1467-2995 en_ZA
dc.identifier.citation Dittberner, MJ, Venter, L & Naidoo, V 2015, 'Accelerated induction of etorphine immobilization in blue wildebeest (Connochaetes taurinus) through the addition of hyaluronidase', Veterinary Anaesthesia and Analgesia, vol. 42, no. 3, pp. 173-177. en_ZA
dc.identifier.issn 1467-2987 (print)
dc.identifier.issn 1467-2995 (online)
dc.identifier.other 10.1111/vaa.12188
dc.identifier.uri http://hdl.handle.net/2263/51332
dc.language.iso en en_ZA
dc.publisher Wiley en_ZA
dc.rights © 2014 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia. Wiley. This is the pre-peer reviewed version of the following article : Accelerated induction of etorphine immobilization in blue wildebeest (Connochaetes taurinus) through the addition of hyaluronidase, Veterinary Anaesthesia and Analgesia, vol. 42, no. 3, pp. 173-177, 2015. doi : 10.1111/vaa.12188. The definite version is available at : http://onlinelibrary.wiley.comjournal/10.1111/(ISSN)1467-2995. en_ZA
dc.subject Azaperone en_ZA
dc.subject Etorphine en_ZA
dc.subject Immobilisation time en_ZA
dc.subject Hyaluronidase en_ZA
dc.subject Blue wildebeest en_ZA
dc.subject Connochaetes taurinus
dc.title Accelerated induction of etorphine immobilization in blue wildebeest (Connochaetes taurinus) through the addition of hyaluronidase en_ZA
dc.type Postprint Article en_ZA


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