Sibutramine, a serotonin-norepinephrine reuptake inhibitor, causes fibrosis in rats

Oberholzer, Hester Magdalena; Van der Schoor, Ciska; Bester, Megan Jean

dc.contributor.author	Oberholzer, Hester Magdalena
dc.contributor.author	Van der Schoor, Ciska
dc.contributor.author	Bester, Megan Jean
dc.date.accessioned	2016-02-10T11:23:49Z
dc.date.issued	2015-07
dc.description.abstract	Sibutramine hydrochloride monohydrate is a weight loss agent indicated for the treatment of obesity. Although it has been banned from most markets, studies are still relevant as it is often a hidden ingredient in herbal and over the counter slimming products. Sibutramine induces liver fibrosis with steatosis in female Sprague-Dawley rats fed a high-energy diet without significant weight gain. In this study, using the same animal model, the effect of Sibutramine on lung morphology was investigated using histological evaluation of the terminal bronchiole and transmission electron microscopy evaluation of the respiratory tissue. From these results Sibutramine was found to induce lung fibrosis in Sprague-Dawley rats as increased collagen synthesis, mast cell accumulation and aggregates of Bronchus Associated Lymphoid Tissue (BALT) in the terminal bronchiole as well as increased collagen deposition in the respiratory tissue was seen.	en_ZA
dc.description.embargo	2016-07-31
dc.description.librarian	hb2015	en_ZA
dc.description.sponsorship	National Research Foundation (NRF)	en_ZA
dc.description.uri	http://www.elsevier.com/locate/etap	en_ZA
dc.identifier.citation	Oberholzer, HM, Van der Schoor, C & Bester, MJ 2015, 'Sibutramine, a serotonin-norepinephrine reuptake inhibitor, causes fibrosis in rats', Environmental Toxicology and Pharmacology, vol. 40, no. 1, pp. 71-76.	en_ZA
dc.identifier.issn	1382-6689 (print)
dc.identifier.issn	1872-7077 (online)
dc.identifier.other	10.1016/j.etap.2015.05.011
dc.identifier.uri	http://hdl.handle.net/2263/51319
dc.language.iso	en	en_ZA
dc.publisher	Elsevier	en_ZA
dc.rights	© 2015 Elsevier B.V. All rights reserved. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Environmental Toxicology and Pharmacology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Environmental Toxicology and Pharmacology, vol. 40, no.1, pp. 71-76, 2015. doi :10.1016/j.etap.2015.05.011.	en_ZA
dc.subject	Sibutramine	en_ZA
dc.subject	Fibrosis	en_ZA
dc.subject	Mast cells	en_ZA
dc.subject	iBALT	en_ZA
dc.subject	Collagen	en_ZA
dc.subject	Bronchus Associated Lymphoid Tissue (BALT)	en_ZA
dc.subject.other	Health sciences article SDG-03
dc.subject.other	SDG-03: Good health and well-being
dc.subject.other	Health sciences article SDG-12
dc.subject.other	SDG-12: Responsible consumption and production
dc.title	Sibutramine, a serotonin-norepinephrine reuptake inhibitor, causes fibrosis in rats	en_ZA
dc.type	Postprint Article	en_ZA