Abstract:
Herein, we describe the effects of Taxol on endothelioma cell growth and migration in vitro and on
vascular tumor growth in vivo. The effects of Taxol on endothelioma cell growth were determined using
the crystal violet assay, while cell migration was measured using the xCELLIgence Real-Time Cell
Analysis system. To study the effects of Taxol on tumor growth, mice were inoculated with endothelioma
cells to induce vascular tumor development and were treated with the drug. At termination, tissue
samples from Taxol-treated and control mice were stained with hematoxylin and eosin for histological
examination, while blood samples were collected for hematological analysis, as well as for the analysis of
the expression of angiogenic markers. In vitro, Taxol inhibited cell growth and migration. The drug also
inhibited vascular tumor growth in mice, and this correlated with a recovery of mice from
thrombocytopenia. Array analysis of blood samples from mice revealed that there was an increase in
the expression of platelet factor 4 and a suppression of the proangiogenic molecule basic fibroblast
growth factor in Taxol-treated animals. Our findings suggest that Taxol may have potential in the
treatment of vascular tumors.
