dc.contributor.author |
Halliday, JoE.B.
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dc.contributor.author |
Knobel, Darryn Leslie
|
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dc.contributor.author |
Allan, Kathryn J.
|
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dc.contributor.author |
De Bronsvoort, B.M.C.
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dc.contributor.author |
Handel, Ian Graham
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dc.contributor.author |
Agwanda, Bernard
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dc.contributor.author |
Cutler, Sally J.
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dc.contributor.author |
Olack, Beatrice
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dc.contributor.author |
Ahmed, Ahmed
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dc.contributor.author |
Hartskeerl, Rudy A.
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dc.contributor.author |
Njenga, M. Kariuki
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dc.contributor.author |
Cleaveland, Sarah
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dc.contributor.author |
Breiman, Robert F.
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dc.date.accessioned |
2014-02-26T08:32:06Z |
|
dc.date.available |
2014-02-26T08:32:06Z |
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dc.date.issued |
2013-09-30 |
|
dc.description.abstract |
Leptospirosis is a widespread but under-reported cause of morbidity and mortality. Global re-emergence
of leptospirosis has been associated with the growth of informal urban settlements in which rodents are thought to be
important reservoir hosts. Understanding the multi-host epidemiology of leptospirosis is essential to control and prevent
disease. A cross-sectional survey of rodents in the Kibera settlement in Nairobi, Kenya was conducted in September–
October 2008 to demonstrate the presence of pathogenic leptospires. A real-time quantitative polymerase chain reaction
showed that 41 (18.3%) of 224 rodents carried pathogenic leptospires in their kidneys, and sequence data identified
Leptospira interrogans and L. kirschneri in this population. Rodents of the genus Mus (37 of 185) were significantly more
likely to be positive than those of the genus Rattus (4 of 39; odds ratio = 15.03). Questionnaire data showed frequent
contact between humans and rodents in Kibera. This study emphasizes the need to quantify the public health impacts of
this neglected disease at this and other urban sites in Africa. |
en |
dc.description.librarian |
am2014 |
en |
dc.description.librarian |
ab2014 |
|
dc.description.sponsorship |
The Wellcome Trust,
United Kingdom (grants 081828/B/06/Z and 096400/Z/11/Z), the
Biotechnology and Biological Sciences Research Council, United Kingdom
(grant BB/J010367/1) and the Medical Research Council, United Kingdom
(grant G0902417 94378). |
en |
dc.identifier.citation |
Halliday, JEB, Knobel, DL, Allan, KJ, De Bronsvoort, BMC, Handel, I, Agwanda, B, Cutler, SJ, Olack, B, Ahmed, A, Hartskeerl, RA, Njenga, MK, Cleaveland, S & Breiman, RF 2013, 'Urban Leptospirosis in Africa : a cross-sectional survey of Leptospira infection in rodents in the Kibera urban settlement, Nairobi, Kenya', American Journal of Tropical Medicine and Hygiene, vol. 89, no. 6, pp. 1095-1102. |
en |
dc.identifier.issn |
0002-9637 (print) |
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dc.identifier.issn |
1476-1645 (online) |
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dc.identifier.other |
10.4269/ajtmh.13-0415 |
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dc.identifier.other |
6602518021 |
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dc.identifier.other |
O-7057-2014 |
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dc.identifier.other |
0000-0002-0425-3799 |
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dc.identifier.uri |
http://hdl.handle.net/2263/36756 |
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dc.language.iso |
en |
en |
dc.publisher |
American Society of Tropical Medicine and Hygiene |
en |
dc.relation.requires |
Adobe Acrobat Reader |
en |
dc.rights |
© 2013 by The American Society of Tropical Medicine and Hygiene |
en |
dc.subject |
Leptospirosis |
en |
dc.subject |
Africa |
en |
dc.subject |
Leptospira infection |
en |
dc.subject |
Rodents |
en |
dc.subject |
Kibera urban settlement, Nairobi, Kenya |
en |
dc.subject.lcsh |
Leptospirosis in animals -- Kenya |
en |
dc.subject.lcsh |
Bacterial diseases in animals |
en |
dc.subject.lcsh |
Rodents -- Diseases |
en |
dc.subject.lcsh |
Rodents as carriers of disease -- Kenya |
en |
dc.title |
Urban leptospirosis in Africa : a cross-sectional survey of leptospira infection in rodents in the Kibera urban settlement, Nairobi, Kenya |
en |
dc.type |
Article |
en |