dc.contributor.author |
Fasina, Folorunso Oludayo
|
|
dc.contributor.author |
Olaokun, Oyinlola Oluwunmi
|
|
dc.contributor.author |
Oladipo, Olusola O.
|
|
dc.contributor.author |
Fasina, Margaret M.
|
|
dc.contributor.author |
Makinde, Adesoji A.
|
|
dc.contributor.author |
Heath, Livio Edward
|
|
dc.contributor.author |
Bastos, Armanda D.S.
|
|
dc.date.accessioned |
2014-01-24T08:56:16Z |
|
dc.date.available |
2014-01-24T08:56:16Z |
|
dc.date.issued |
2013-06-19 |
|
dc.description.abstract |
BACKGROUND: African swine fever (ASF), a highly contagious fatal acute haemorrhagic viral disease of pigs currently
has no treatment or vaccination protocol and it threatens the pig industry worldwide. Recent outbreaks were
managed by farmers with ethnoveterinary preparations with various claims of effectiveness.
RESULTS: We identified 35 compounds using GC-MS protocol and ASF virus (NIG 99) was significantly reduced by
some extracts and fractions of the plant. However, the plant was poorly extracted by water and cytotoxicity was
found to be a major problem with the use of the plant since its extracts also reduced the primary cells used in the
assay.
CONCLUSION: It is confirmed that the plant has antiviral potentials against ASF virus and farmers’ claims seem to
have certain degree of veracity, but finding the best means of exploring the potential of the plant while reducing
its cytotoxic effect in-vitro and in-vivo will be necessary. |
en |
dc.description.librarian |
ab2014 |
|
dc.description.sponsorship |
The Executive Secretary, Agricultural Research
Council of Nigeria, Abuja for part funding of this project under the Project
Code 025060410100000 (Development of rapid and effective Diagnostic and
Control tools for African Swine Fever) |
en |
dc.description.uri |
http://www.biomedcentral.com/1746-6148/9/120 |
en |
dc.identifier.citation |
Fasina et al.: Phytochemical analysis and in-vitro anti-African swine fever virus activity of extracts and fractions of Ancistrocladus uncinatus, Hutch and Dalziel (Ancistrocladaceae). BMC Veterinary Research 2013 9:120. |
en |
dc.identifier.issn |
1746-6148 |
|
dc.identifier.other |
10.1186/1746-6148-9-120 |
|
dc.identifier.other |
16416667800 |
|
dc.identifier.other |
H-9699-2013 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/33083 |
|
dc.language.iso |
en |
en |
dc.publisher |
BioMed Central |
en |
dc.relation.requires |
Adobe Acrobat Reader |
en |
dc.rights |
© 2013 Fasina et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative
Commons Attribution License |
en |
dc.subject |
Ancistrocladus uncinatus |
en |
dc.subject |
Antiviral |
en |
dc.subject.lcsh |
African swine fever virus |
en |
dc.subject.lcsh |
Swine -- Diseases |
en |
dc.subject.lcsh |
Plant extracts |
en |
dc.title |
Phytochemical analysis and in-vitro anti-African swine fever virus activity of extracts and fractions of Ancistrocladus uncinatus, Hutch and Dalziel (Ancistrocladaceae) |
en |
dc.type |
Article |
en |