• Antibiofilm properties of selected Lactobacillus species and their mechanism of action against Listeria monocytogenes 

  Masebe, Reabetswe Dolly (University of Pretoria, 2022-01)

  The disastrous effects of the foodborne pathogen Listeria monocytogenes have been observed overtime by global listeriosis outbreaks claiming many lives. The spread of this pathogen is being reported at high levels with ...
• Chemically synthetic mycolic acids as vaccine adjuvants 

  Ranchod, Heena (University of Pretoria, 2014)

  No abstract
• Development and evaluation of a bi-enzymatic nitric oxide reduction system 

  Garny, Seike (University of Pretoria, 2013)

  Nitric oxide is a small diatomic molecule and is part of the nitrogen radical species. As a gas, it diffuses easily across cell membranes and is involved in numerous physiological processes and inflammation. This peculiar ...
• Transcriptional regulation underlying the quantitative genetic response of maize to grey leaf spot disease 

  Christie, Nanette (University of Pretoria, 2014)

  Cercospora zeina causes grey leaf spot (GLS), a yield-limiting disease on maize. The main objective of this study was to exploit maize gene expression data to dissect the quantitative disease response to C. zeina infection. ...
• Basal promoter landscape in Eucalyptus grandis : annotation of distal transcription start sites and core promoter usage 

  Van Jaarsveld, Ida CecIlia (University of Pretoria, 2014)

  Transcription is a complex biological phenomenon, whereby RNA is transcribed from single stranded template DNA by assembling targeted regulatory inputs at the promoter region. Transcription is regulated through many ...
• Reverse vaccinology based identification of anti- Rhipicephalus microplus vaccine candidates 

  Stutzer, Christian (University of Pretoria, 2013)

  The rapid geographic expansion of the cattle tick species, Rhipicephalus microplus, as well as the introduction of diseases into previously unaffected areas and the increased incidence of acaricide resistance in this species ...
• Investigating the anti-inflammatory properties of epigallocatechin gallate from green tea Camellia sinensis (L) O.Kuntze in mammalian innate immunity 

  Nyide, Nolwando Babalwa (University of Pretoria, 2020)

  Humans are hypersensitive to lipopolysaccharide, a gram-negative bacterial endotoxin that stimulates an inflammatory response by binding to the extracellular domain of TLR4 of innate immune cells. Through the MyD88-dependent ...
• Triazolyl Ru(II), Os(II), and Ir(III) complexes as potential HIV-1 entry inhibitors 

  Putterill, Brandon Marquand Fraser (University of Pretoria, 2021)

  Background: The human immunodeficiency virus (HIV) is the cause of the acquired immunodeficiency syndrome (AIDS). AIDS is fatal if not treated appropriately. Although there are treatment options for the infection, there ...
• In silico and in vitro inhibition of α- glucosidase and α-amylase by compounds from culinary herbs and spices, for possible treatment of type 2 diabetes 

  Tolmie, Morné (University of Pretoria, 2020)

  Diabetes is one of the largest health challenges of the 21st century and is amongst the top 10 causes of death globally. There is no cure for type 2 diabetes (T2DM) and the search for new and improved treatments is ongoing. ...
• Metabolomic markers for agronomic traits and their possible biochemical mechanisms in black tea Camellia sinensis (L.) O. Kuntze 

  Nyarukowa, Christopher (University of Pretoria, 2020-11-17)

  Climate change is causing droughts, which are affecting crop production globally, and disrupting plant metabolism. Due to the unpredictable natural droughts that occur, causing tea farmers significant losses in tea estates, ...
• The contribution of Plasmodium falciparum genetic diversity to differentiate drug response in gametocytes 

  Maboane, Suzan (University of Pretoria, 2020)

  Late-stage gametocytes of P. falciparum parasites are responsible for the ongoing human-to-mosquito transmission of malaria disease. To block transmission, novel gametocytocidal compounds are required. It is thus important ...
• Novel acid-labile and targeted nanoparticles as possible antimalarial drug delivery systems 

  Leshabane, Meta Kgaogelo (University of Pretoria, 2020)

  The multistage life cycle of malaria-causing P. falciparum is complex, making prevention and treatment difficult. As a result of resistance to many antimalarial drugs, novel compounds with unexplored targets are constantly ...
• Metabolomic analysis of maize (Zea mays&nbsp L.) seedlings treated with selected plant growth promoting rhizobacteria 

  Otukpa, Faith Obiye (University of Pretoria, 2019)

  Global food production has significantly increased mainly due to the use of high-yield crop varieties, fertilisers, fungicides and pesticides, and improved irrigation methods. Despite the increase in production, there has ...
• Exploring the evolution of drug resistance in mycobacterium using whole genome sequencing data 

  Muzondiwa, Dillon (University of Pretoria, 2019)

  Mycobacterium tuberculosis (Mtb) remains a global challenge that has been worsened by the emergence of drug resistant strains of Mtb. We used publicly available Next Generation Sequencing (NGS) and drug susceptibility (DST) ...
• Metabolic profiling for identification of potential biomarkers in potato tuber extracts associated with tolerance to Spongospora subterranea f. sp. subterranea infection 

  Modisane, Gontse Kehumile Joyce (University of Pretoria, 2019)

  Potatoes are popular and reliable crops all over the world. Unfortunately, its production is threatened by detrimental factors such as fungi, bacteria and viruses that attack potatoes during growth and storage. Among all ...
• Structural and inhibition studies of thiamine monosphosphate kinase from Mycobacterium tuberculosis 

  Dlamini, Lenye Sebenzile (University of Pretoria, 2020)

  Vitamin B1 is an indispensable co-factor for various enzymes inter alia in the Krebs cycle, pentose phosphate pathway, nucleotide and amino acid synthesis. Due to its importance in metabolism, proteins involved in the ...
• Selectively modifying the interaction of human Tuba SH3-6 domain with listerial InlC and N-WASP 

  Boafoh, Kofi Kwantwi (University of Pretoria, 2020)

  Listeriosis is a food-borne disease caused by the gram-positive bacterium Listeria monocytogenes. In extreme cases, listeriosis can lead to sepsis and meningitis. The bacterium uses host actin cytoskeleton for its own ...
• Detection of acetone using nanostructured WO3 for diabetes mellitus monitoring applications 

  Saasa, Raseputuka Valentine (University of Pretoria, 2020)

  Diabetes mellitus which is characterized by a high levels of blood glucose is a major source of mortality, morbidity and health costs worldwide. Major gaps exist in efforts to comprehend the burden nationally and globally, ...
• Antifungal mode of action studies of an antimicrobial peptide, Os, in planktonic Candida albicans (ATCC 90028) 

  Moller, Dalton Sharl (University of Pretoria, 2020-07)

  Candida albicans is a fungus found in the normal biota of humans, but in immuno-compromised individuals, C. albicans forms complex biofilms on the surface of medical prosthetics, skin, oral cavities, the urinary tract, ...
• The effects of medicinal plant extracts on the microbial, biofilm and autolytic activity of several pathogenic bacteria. 

  Demetriou, Demetra Danielle (University of Pretoria, 2018)

  More people are aware of the problems with drugs and are reverting to herbal (plant) and over-the-counter medications. The conclusion made is the urgency to study new plants for antimicrobial activity. Various plant extracts ...

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