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Browsing Health Sciences by UP Author "Cassol, Sharon"
Now showing items 1-13 of 13
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Danaviah, Sivapragashini; De Oliveira, Tulio; Gordon, Michelle; Govender, Shunmugam; Chelule, Paul; Pillay, Sureshnee; Naicker, Thajasvarie; Cassol, Sharon; Ndung'u, Thumbi (Mary Ann Liebert, 2016-03)Extrapulmonary tuberculosis (TB) is a significant public health challenge in South Africa and worldwide, largely fuelled by the HIV epidemic. In spinal TB, Mycobacteria infect the spinal column without dissemination to ...
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De Oliveira, Tulio; Deforche, Koen; Cassol, Sharon; Salminen, M.; Paraskevis, D.; Seebreghts, C.; Snoeck, J.; Janse van Rensburg, Estrelita; Wensing, A.M.J.; Van der Vijver, D.A.; Boucher, C.A.; Camacho, R.; Vandamme, Anne-Mieke (Oxford University Press, 2005-10-01)Motivation: Genetic analysis of HIV-1 is important not only for vaccine development, but also to guide treatment strategies, track the emergence of new viral variants and ensure that diagnostic assays are contemporary and ...
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Malherbe, Glen Pierre; Steel, Helen C.; Cassol, Sharon; De Oliveira, Tulio; Seebregts, Christopher J.; Anderson, Ronald; Cassol, Edana; Rossouw, Theresa M. (Hindawi Publishing Corporation, 2014-04-06)Please read abstract in article.
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Danaviah, S.; Govender, S.; Cassol, Sharon (Lippincott Williams and Wilkins, 2007-07)Approximately 2 million South Africans are HIV/TB coinfected, and many develop skeletal disease. The resurgence of spinal tuberculosis, including atypical forms, is due largely to HIV-associated immune suppression. We ...
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Microbial translocation : a marker of advanced HIV-1 infection and a predictor of treatment failure? Cassol, Edana; Rossouw, Theresa M.; Seebregts, Christopher J.; Cassol, Sharon (University of Chicago Press, 2011-03-01)We agree that the issue of whether microbial translocation (MT) is a cause or consequence of human immunodeficiency virus type 1 (HIV-1) disease progression is an important question that can only be addressed through ...
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Cassol, Sharon; Gordon, Michelle; De Oliveira, Tulio; Bishop, Karen; Coovadia, H.M.; Madurai, L.; Engelbrecht, Susan; Janse van Rensburg, Estrelita; Mosam, A.; Smith, A. (American Society for Microbiology, 2003-02)The KwaZulu-Natal region of South Africa is experiencing an explosive outbreak of Human Immunodeficiency Virus Type 1 (HIV-1) Subtype C infections. Understanding the genetic diversity of C viruses and the biological ...
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Cassol, Sharon; Zur Megede, Jan; Engelbrecht, Susan; De Oliveira, Tulio; Scriba, Thomas Jens; Janse van Rensburg, Estrelita; Barnett, Susan W. (Mary Ann Liebert, 2002-11)Understanding the origin, distribution, and evolving dominance of HIV-1 subtype C strains is an important component in the design and evaluation of a globally effective AIDS vaccine. To better understand subtype C viruses, ...
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Kanthula, Ruth; Rossouw, Theresa M.; Feucht, Ute Dagmar; Van Dyk, Gisela; Beck, Ingrid A.; Silverman, Rachel; Olson, Scott; Salyer, Christen; Cassol, Sharon; Frenkel, Lisa M. (Lippincott Williams and Wilkins, 2017-05)OBJECTIVES : We set out to examine the prevalence and persistence of mutations conferring high-level non-nucleoside-reverse-transcriptase (NNRTI)-resistance in a cohort of HIV-infected children who had failed prophylaxis ...
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Cassol, Edana; Malfeld, Susan; Mahasha, Phetole; Van der Merwe, Schalk Willem; Cassol, Sharon; Seebregts, Christopher J.; Alfano, Massimo; Poli, Guido; Rossouw, Theresa M. (University of Chicago Press, 2010-07)BACKROUND: Microbial translocation contributes to immune activation and disease progression during chronic human immunodeficiency virus type 1 (HIV-1) infection. However, its role in the African AIDS epidemic remains c ...
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Manasa, Justen; Katzenstein, David; Cassol, Sharon; Newell, Marie-Louise; De Oliveira, Tulio (Mary Ann Liebert, 2012)HIV-1 transmitted drug resistance (TDR) could reverse the gains of antiretroviral rollout. To ensure that current first-line therapies remain effective, TDR levels in recently infected treatment-naive patients need to be ...
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Alcantara, Luiz Carlos Junior; Cassol, Sharon; Libin, Pieter; Deforche, Koen; Pybus, Oliver G.; Van Ranst, Marc; Galvao-Castro, Bernardo; Vandamme, Anne-Mieke; De Oliveira, Tulio (Oxford University Press, 2009-07)Human immunodeficiency virus type-1 (HIV-1), hepatitis B and C and other rapidly evolving viruses are characterized by extremely high levels of genetic diversity. To facilitate diagnosis and the development of prevention ...
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Cassol, Sharon; Alcantara, Luiz Carlos Junior; De Oliveira, Tulio; Gordon, Michelle; Pybus, Oliver G.; Mascarenhas, Rita E.; Seixas, Magda O.; Gonçalves, Marilda; Hlela, Carol; Galvao-Castro, Bernardo (Lippincott Williams & Wilkins, 2006-03)We compared the genetic diversity of the Brazilian human T-cell lymphotropic virus type 1 isolates with those found in KwaZulu–Natal (KZN), South Africa, and with the genetic background of the hosts. The seroprevalence ...
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Cassol, Sharon; De Oliveira, Tulio; Engelbrecht, Susan; Janse van Rensburg, Estrelita; Gordon, Michelle; Bishop, Karen; Zur Megede, Jan; Barnett, Susan W. (American Society for Microbiology, 2003-09)Naturally occurring polymorphisms in the protease of human immunodeficiency virus type 1 (HIV-1)subtype C would be expected to lead to adaptive (compensatory) changes in protease cleavage sites. To test this hypothesis, ...
Now showing items 1-13 of 13