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Browsing Health Sciences by UP Author "Anderson, Ronald"
Now showing items 21-40 of 130
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Cholo, Moloko C.; Steel, Helen C.; Fourie, P.B. (Petrus Bernardus); Germishuizen, Willem Andreas; Anderson, Ronald (Oxford University Press, 2012-02)Clofazimine, a lipophilic riminophenazine antibiotic, possesses both antimycobacterial and anti-inflammatory activities. However, its efficacy has been demonstrated only in the treatment of leprosy, not in human tuberculosis, ...
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Anderson, Ronald; Theron, Annette J.; Nel, Jan Gert; Durandt, Chrisna; Cholo, Moloko C.; Feldman, Charles; Tintinger, Gregory Ronald (Frontiers Media, 2018-11-20)Although the inclusion of the cationic amphiphilic, anti-mycobacterial agent, clofazimine, in the chemotherapeutic regimens of patients with multidrug-resistant tuberculosis (TB) has contributed to improved outcomes, ...
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Feldman, Charles; Anderson, Ronald (Elsevier, 2015-08)Despite advances in antimicrobial chemotherapy and access to sophisticated intensive care facilities, bacterial community-acquired pneumonia (CAP) continues to carry an unacceptably high mortality rate of 10% to 15% in ...
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Feldman, Charles; Anderson, Ronald (Lippincott, Williams & Wilkins, 2016-10)PURPOSE OF REVIEW : Describe recent studies that may impact on the management of community-acquired pneumonia (CAP). RECENT FINDINGS : CAP continues to be associated with a considerable burden of disease. Diagnosis remains ...
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Meyer, Pieter Willem Adriaan; Ally, Mahmood Moosa Tar Mahomed; Hodkinson, Bridget; Anderson, Ronald; Tikly, Mohammed (Springer, 2018-06)PURPOSE : A retrospective comparison of the prevalence and diagnostic value of anti-Sa, anti-CEP-1, and anti-MCV autoantibodies relative to those of the established autoantibodies, composite RF and anti-CCP-IgG used routinely ...
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Anderson, Ronald; Steel, Helen C.; Cockeran, Riana; Von Gottberg, Anne; De Gouveia, L.; Klugman, Keith P.; Mitchell, Timothy J.; Feldman, Charles (Oxford University Press, 2007-11)OBJECTIVES: To compare the effects of subinhibitory concentrations of amoxicillin, ceftriaxone, azithromycin, clarithromycin, erythromycin, telithromycin, clindamycin, ciprofloxacin, moxifloxacin, tobramycin and doxycycline ...
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Theron, Annette J.; Steel, Helen C.; Rapoport, Bernardo Leon; Anderson, Ronald (MDPI Publishing, 2020-11-20)Tumor cells are particularly adept at exploiting the immunosuppressive potential of neutrophils as a strategy to achieve uncontrolled proliferation and spread. Recruitment of neutrophils, particularly those of an immature ...
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Feldman, Charles; Anderson, Ronald (AME Publishing Company, 2016-03)Improving the outcome of patients with community-acquired pneumonia (CAP) is an ongoing challenge, even in the setting of significant advances in antimicrobial chemotherapy and critical care. Recognition of the underlying ...
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Theron, Annette J.; Steel, Helen C.; Tintinger, Gregory Ronald; Gravett, Cornelia M.; Anderson, Ronald; Feldman, Charles (Hindawi Publishing Corporation, 2014)Cysteinyl leukotrienes (cysLTs) are produced predominantly by cells of the innate immune system, especially basophils, eosinophils, mast cells, and monocytes/macrophages. Notwithstanding potent bronchoconstrictor activity, ...
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Hodkinson, Bridget; Meyer, Pieter Willem Adriaan; Musenge, Eustasius; Ally, Mahmood Moosa Tar Mahomed; Wadee, Ahmed A.; Anderson, Ronald; Tikly, Mohammed (Springer, 2010-02)To establish the diagnostic utility of the anticyclic- citrullinated peptide antibody (aCCP) test in Black South Africans with early rheumatoid arthritis (RA). A cross-sectional study comparing the rheumatoid factor ...
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Meyer, Pieter Willem Adriaan; Ally, Mahmood Moosa Tar Mahomed; Hodkinson, Bridget; Anderson, Ronald; Tikly, Mohammed (Makerere University Medical School, 2018-06)BACKGROUND : The immunoglobulin A isotypes of anti-cyclic citrullinated peptide antibodies (ACPA) and rheumatoid factor (RF) are associated with disease severity and progression in Caucasian rheumatoid arthritis (RA) ...
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Steel, Helen C.; Venter, Willem Daniel Francois; Theron, Annette J.; Anderson, Ronald; Feldman, Charles; Arulappan, Natasha; Rossouw, Theresa M. (MDPI, 2021-01-29)Systemic biomarkers of inflammation, including cytokines and chemokines, are potentially useful in the management of both HIV infection and non-AIDS-defining disorders. However, relatively little is known about the utility ...
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Madzime, Morris; Theron, Annette J.; Anderson, Ronald; Tintinger, Gregory; Steel, Helen C.; Meyer, Pieter Willem Adriaan; Nel, Jan Gert; Feldman, Charles; Rossouw, Theresa M. (Taylor and Francis, 2022)Please read abstract in the article.
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Opolot, John O.; Theron, Annette J.; MacPhail, Patrick; Feldman, Charles; Anderson, Ronald (Makerere University Medical School, 2017-06)BACKGROUND : Chronic inflammation, possibly exacerbated by cigarette smoking, is considered to be the primary cause of pulmonary damage in patients with tuberculosis (TB). However, the mechanisms which underpin these ...
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Effects of cigarette smoke condensate on growth and biofilm formation by Mycobacterium tuberculosis Cholo, Moloko C.; Rasehlo, Sam Sipho M.; Venter, Eudri; Venter, Chantelle; Anderson, Ronald (Hindawi Publishing, 2020-08)BACKGROUND AND OBJECTIVES : Cigarette smoke (CS) is a major risk factor contributing to the burden of tuberculosis. Little is known, however, about the effects of CS exposure on growth and persistence of Mycobacterium ...
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Cockeran, Riana; Steel, Helen C.; Wolter, Nicole; De Gouveia, L.; Von Gottberg, Anne; Klugman, Keith P.; Leanord, A.T.; Inverarity, D.J.; Mitchell, Timothy J.; Feldman, Charles; Anderson, Ronald (Scientific Research Publishing Inc, 2012-02)AIM: To investigate the effects of exposure of a macrolide-resistant [erm(B)-expressing] strain of Streptococcus pneumo- niae (strain 2507) to clarithromycin (0.5 and 5 mg/L) added at the outset and 6 hours after initiation ...
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Mothiba, Maborwa Tebogo; Anderson, Ronald; Fourie, Bernard P.; Germishuizen, Willem Andreas; Cholo, Moloko C. (Elsevier, 2015-03)Mycobacteria form lipid-rich biofilms that restrict the efficacy of antimicrobial chemotherapy, possibly necessitating the use of lipophilic antibiotics. In the current study, the activity of one such agent, clofazimine, ...
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Richards, Guy A.; Theron, Annette J.; Tintinger, Gregory Ronald; Anderson, Ronald (MDPI Publishing, 2018-05-14)Dabigatran is an oral direct thrombin inhibitor, and rivaroxaban, a factor Xa inhibitor. Dabigatran has been implicated in the etiology of acute coronary syndromes and as these occur following inflammatory changes in the ...
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Potjo, Moliehi; Cockeran, Riana; Theron, Annette J.; Feldman, Charles; Anderson, Ronald (Molecular Diversity Preservation International, 2010)Moxifloxacin is useful in the treatment of respiratory infections, including community-acquired pneumonia, and also shows promise in the treatment of tuberculosis, a clinical setting which necessitates extended administration ...
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Steel, Helen C.; Venter, Willem Daniel Francois; Theron, Annette J.; Anderson, Ronald; Feldman, Charles; Kwofie-Mensah, M.; Cronje, Tanita; Arullappan, Natasha; Rossouw, Theresa M. (Hindawi Publishing, 2018-12-09)Like HIV infection, smoking, which is common among HIV-infected persons, is associated with chronic, systemic inflammation. However, the possible augmentative effects of HIV infection and smoking and other types of tobacco ...
Now showing items 21-40 of 130