Cardiovascular effects of epidural morphine or ropivacaine in isoflurane-anaesthetised pigs during surgical devascularisation of the liver

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dc.contributor.author Stegmann, George F.
dc.date.accessioned 2010-10-27T07:24:44Z
dc.date.available 2010-10-27T07:24:44Z
dc.date.issued 2010
dc.description.abstract The cardiovascular effects of non-abdominal and abdominal surgery during isoflurane anaesthesia (A-group) or isoflurane anaesthesia supplemented with either epidural ropivacaine (AR-group; 0.75 % solution, 0.2 m /kg) or morphine (AM-group; 0.1 mg/kg diluted in saline to 0.2m /kg) were evaluated in 28 healthy pigs with a mean body weight of 30.3 kg SD ± 4.1 during surgical devascularisation of the liver. Anaesthesia was induced with the intramuscular injection of midazolam (0.3 mg/kg) and ketamine (10 mg/kg). Anaesthesia was deepened with intravenous propofol to enable tracheal intubation and maintained with isoflurane on a circle rebreathing circuit. The vaporiser was set at 2.5%for the A-group and 1.5%for the AR- and AM-groups. Differences between treatment groups were not statistically significant (P>0.05) for any of the variables. Differences betweenAMand AR-groups were marginally significant heart rate (HR) (P = 0.06) and mean arterial blood pressure (MAP) (P = 0.08). Within treatment groups, differences for the A-group were statistically significant (P<0.05) between non-abdominal and abdominal surgery for HR, systolic blood pressure, diastolic blood pressure (DIA) andMAP.Within the AM-group differences were statistically significant (P < 0.05) for DIA and MAP, and within the AR group differences for all variables were not statistically significant (P > 0.05). It was concluded that in isoflurane-anaesthetised pigs, the epidural administration of ropivacaine decreased heart rate and improved arterial blood pressure during surgery. en
dc.identifier.citation Stegmann, GF 2010, 'Cardiovascular effects of epidural morphine or ropivacaine in isoflurane-anaesthetised pigs during surgical devascularisation of the liver', Journal of the South African Veterinary Association, vol. 81, no. 3, pp. 143–147. [http://www.journals.co.za/ej/ejour_savet.html] en
dc.identifier.issn 0038-2809
dc.identifier.uri http://hdl.handle.net/2263/15080
dc.language.iso en en
dc.publisher South African Veterinary Association en
dc.rights South African Veterinary Association en
dc.subject Anaesthesia en
dc.subject Cardiovascular effects en
dc.subject Epidural anaesthesia en
dc.subject Morphine en
dc.subject Pigs en
dc.subject Ropivacaine en
dc.subject.lcsh Veterinary anesthesia -- South Africa en
dc.subject.lcsh Anesthesiology -- Research en
dc.title Cardiovascular effects of epidural morphine or ropivacaine in isoflurane-anaesthetised pigs during surgical devascularisation of the liver en
dc.type Article en


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