The effects of firocoxib (Previcox™) in geriatric dogs over a period of 90 days

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dc.contributor.author Joubert, Kenneth E.
dc.date.accessioned 2010-03-17T08:29:09Z
dc.date.available 2010-03-17T08:29:09Z
dc.date.issued 2009-09
dc.description.abstract The long-term use of non-steroidal anti-inflammatory agents in geriatric dogs with osteoarthritis has not been well studied in veterinary medicine. This study evaluated the effects of firocoxib administered to dogs over 7 years of age for 90 days. Pain and lameness scores were evaluated by the owner weekly for the 1st month and then biweekly through to the end of the study, the veterinarian evaluated the dogs monthly. Serum chemistry, including urea, creatinine, alanine transferase, aspartate transaminase, bile acids and bilirubin, urine specific gravity and a urine dipstick, were performed at monthly intervals. Forty-five dogs were enrolled into the treatment group and 9 into the control group. A total of 33 dogs completed the trial in the treatment group and 8 in the control group. Lameness and pain scores were found to be significantly lower in the treated group from day 30 for most parameters evaluated. Bile acids (although not comparable to controls, with higher mean value and a high standard deviation in the control group; in addition the control group had increased bile acids at day 0) and urea (within normal reference range provided (WNL)) were significantly different in the treatment group between days 0 and 90. Urea(WNL) on days 30 and 90 and creatinine (WNL) on day 90 were significantly different between the control group and the treatment group. The most common adverse events reported were diarrhoea, vomition, dark faeces and anorexia. This study showed that firocoxib was effective in managing pain associated with osteoarthritis for 90 days. Despite the geriatric high-risk population used for this study, minimal biochemical changes were seen and adverse drug events seen were in agreement with those previously reported. en
dc.description.sponsorship Merial South Africa (Pty) Ltd en
dc.identifier.citation Joubert, KE 2009, 'The effects of firocoxib (Previcox™) in geriatric dogs over a period of 90 days', Journal of the South African Veterinary Association, vol. 80, no. 3, pp. 179-184. [http://www.journals.co.za/ej/ejour_savet.html] en
dc.identifier.issn 0038-2809
dc.identifier.uri http://hdl.handle.net/2263/13508
dc.language.iso en en
dc.publisher South African Veterinary Association en
dc.rights South African Veterinary Association en
dc.subject Adverse events en
dc.subject Canine en
dc.subject Lameness en
dc.subject Firocoxib en
dc.subject Geriatric en
dc.subject Long term en
dc.subject Non-steroidal anti-inflammatory drugs en
dc.subject Pain control en
dc.subject.lcsh Lameness in dogs en
dc.subject.lcsh Drugs -- Research en
dc.subject.lcsh Veterinary drugs -- South Africa en
dc.title The effects of firocoxib (Previcox™) in geriatric dogs over a period of 90 days en
dc.type Article en


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