Browsing by UP Author "Hanyroup, Sharika"

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Functional rescue of inactivating mutations of the human neurokinin 3 receptor using pharmacological chaperones

Anderson, Ross Calley; Hanyroup, Sharika; Song, Yong Bhum; Mohamed-Moosa, Zulfiah; Van den Bout, Iman; Schwulst, Alexis C.; Kaiser, Ursula B.; Millar, Robert P.; Newton, Claire L. (MDPI, 2022-04-21)

G protein-coupled receptors (GPCRs) facilitate the majority of signal transductions across cell membranes in humans, with numerous diseases attributed to inactivating GPCR mutations. Many of these mutations result in ...
Rescue of cell surface expression and signaling of mutant follicle-stimulating hormone receptors

Hanyroup, Sharika; Anderson, Ross Calley; Nataraja, Selvaraj; Yu, Henry N.; Millar, Robert P.; Newton, Claire L. (Oxford University Press, 2021-12)

Mutations in G protein-coupled receptors (GPCRs) underlie numerous diseases. Many cause receptor misfolding and failure to reach the cell surface. Pharmacological chaperones are cell-permeant small molecules that engage ...

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