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Browsing by UP Author "Burger, Pieter Buys"
Now showing items 1-7 of 7
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Bekker, Shani; Burger, Pieter Buys; Van Staden, Vida (Elsevier, 2017-03)VP7 is the major core protein of orbiviruses and is essential for virion assembly. African horse sickness virus (AHSV) VP7 self-assembles into highly insoluble crystalline particles – an attribute that may be related to ...
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Niemand, Jandeli; Burger, Pieter Buys; Verlinden, Bianca K.; Reader, Janette; Joubert, Annie M.; Kaiser, Annette; Louw, Abraham Izak; Kirk, Kiaran; Phanstiel IV, Otto; Birkholtz, Lyn-Marie (American Society for Microbiology, 2013-06)Anthracene-polyamine conjugates inhibit the in vitro proliferation of the intraerythrocytic human malaria parasite, Plasmodium falciparum, with IC50 values in the nM-μM range. The compounds are taken up into the ...
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Mpangase, Phelelani Thokozani; Szolkiewicz, Michal Jerzy; Le Grange, Misha; Smit, Jeanre H.; Burger, Pieter Buys; Joubert, Fourie (BioMed Central, 2013-03-28)BACKGROUND: Drug resistance to anti-malarial compounds remains a serious problem, with resistance to newer pharmaceuticals developing at an alarming rate. The development of new anti-malarials remains a priority, and ...
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Reeksting, S.B. (Shaun Bernard); Muller, Ingrid B.; Burger, Pieter Buys; Burgos, Emmanuel S.; Salmon, Laurent; Louw, Abraham Izak; Birkholtz, Lyn-Marie; Wrenger, Carsten (Portland Press on behalf of the Biochemical Society, 2013)Malaria tropica is a devastating infectious disease caused by Plasmodium falciparum. This parasite synthesizes vitamin B6 de novo via the pyridoxal 5-phosphate (PLP) synthase enzymatic complex consisting of PfPdx1 and ...
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Burger, Pieter Buys; Williams, Marni; Sprenger, Janina; Reeksting, S.B. (Shaun Bernard); Botha, M.E. (Mariette); Muller, Ingrid B.; Joubert, Fourie; Birkholtz, Lyn-Marie; Louw, Abraham Izak (BioMed Central, 2015-02-05)BACKGROUND : Plasmodium falciparum is the most pathogenic of the human malaria parasite species and a major cause of death in Africa. It’s resistance to most of the current drugs accentuates the pressing need for ...
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Le Roux, Dina; Burger, Pieter Buys; Niemand, Jandeli; Grobler, Anne; Urbán, Patricia; Fernàndez-Busquets, Xavier; Barker, Robert H.; Serrano, Adelfa; Louw, Abraham Izak; Birkholtz, Lyn-Marie (Elsevier, 2014-04)S-adenosyl-L-methionine decarboxylase (AdoMetDC) in the polyamine biosynthesis pathway has been identified as a suitable drug target in Plasmodium falciparum parasites, which causes the most lethal form of malaria. ...
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Burger, Pieter Buys; Birkholtz, Lyn-Marie; Joubert, Fourie; Haider, Nashya; Walter, Rolf D.; Louw, Abraham Izak (Elsevier, 2007-02)Spermidine synthase is currently considered as a promising drug target in the malaria parasite, Plasmodium falciparum, due to the vital role of spermidine in the activation of the eukaryotic translation initiation factor ...
Now showing items 1-7 of 7