Browsing by Subject "Immunosuppression"

Browsing by Subject "Immunosuppression"

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  • Competing endogenous RNA (ceRNA) networks and splicing switches in cervical cancer : HPV oncogenesis, clinical significance and therapeutic opportunities 
    Basera, Afra; Hull, Rodney; Demetriou, Demetra Danielle; Bates, David O.; Kaufmann, Andreas Martin; Dlamini, Zodwa; Marima, Rahaba (MDPI, 2022-09-16)
    Cervical cancer (CC) is the primary cause of female cancer fatalities in low-middle-income countries (LMICs). Persistent infections from the human papillomavirus (HPV) can result in cervical cancer. However, numerous ...
  • Contrasting immunopathogenic and therapeutic roles of granulocyte colony-stimulating factor in cancer 
    Theron, Annette J.; Steel, Helen C.; Rapoport, Bernardo Leon; Anderson, Ronald (MDPI Publishing, 2020-11-20)
    Tumor cells are particularly adept at exploiting the immunosuppressive potential of neutrophils as a strategy to achieve uncontrolled proliferation and spread. Recruitment of neutrophils, particularly those of an immature ...
  • Fatal congenital anaplasmosis associated with bovine viral diarrhoea virus (BVDV) infection in a crossbred calf 
    Pypers, A.R.; Holm, Dietmar Erik; Williams, June Heather (South African Veterinary Association, 2011-09)
    Clinical disease resulting from the vertical transmission of Anaplasma marginale has only been reported on 5 occasions despite studies demonstrating successful in utero transmission. During the reported experimental ...
  • High mobility group box 1 in human cancer 
    Rapoport, Bernardo Leon; Steel, Helen C.; Theron, Annette J.; Heyman, Liezl; Smit, Teresa; Ramdas, Yastira; Anderson, Ronald (MDPI, 2020-07)
    High mobility group box 1 (HMGB1) is an extremely versatile protein that is located predominantly in the nucleus of quiescent eukaryotic cells, where it is critically involved in maintaining genomic structure and function. ...
  • Immunosuppression in new-born lambs 
    Broekman, J.; Eksteen, P.A.L.; Verwoerd, Daniel Wynand; De Kock, V.E.; Bigalke, R.D.; Cameron, Colin McKenzie; Gilchrist, Frances M.C.; Morren, A.J.; Verster, Anna J.M.; Verwoerd, Daniel Wynand; Walker, Jane B. (Pretoria : The Government Printer, 1977)
    A novel technique, based on cytotoxicity-neutralization, was developed for the in vitro titration of anti-sheep lymphocyte and anti-sheep macrophage sera. The titres obtained for a number of antisera were compared with ...
  • Immunosuppressive signaling pathways as targeted cancer therapies 
    Setlai, Botle Precious; Hull, Rodney; Bida, Nndweleni Meshack; Durandt, Chrisna; Mulaudzi, Thanyani Victor; Chatziioannou, Aristotelis; Dlamini, Zodwa (MDPI, 2022-03)
    Immune response has been shown to play an important role in defining patient prognosis and response to cancer treatment. Tumor-induced immunosuppression encouraged the recent development of new chemotherapeutic agents that ...
  • Phylogenetic analysis of canine distemper virus in South African wildlife 
    Loots, Angelina K.; Mokgokong, Prudent S.; Mitchell, Emily P.; Venter, Estelle Hildegard; Kotze, Antoinette; Dalton, Desire Lee (Public Library of Science, 2018-07-18)
    Canine distemper virus (CDV) causes a severe contagious disease in a broad range of hosts. This is the first study to genetically characterise CDV strains from four different wildlife species in South Africa. The ...
  • Radionuclide imaging of invasive fungal disease in immunocompromised hosts 
    Lawal, Ismaheel Opeyemi; Mokoala, K.M.G. (Kgomotso); Kgatle, Mankgopo; Dierckx, Rudi A.J.O.; Glaudemans, Andor W.J.M.; Sathekge, Mike Machaba; Ankrah, Alfred O. (MDPI, 2021-11-06)
    Invasive fungal disease (IFD) leads to increased mortality, morbidity, and costs of treatment in patients with immunosuppressive conditions. The definitive diagnosis of IFD relies on the isolation of the causative fungal ...
  • Review manuscript targeting of the neutrophil as an adjunctive strategy in non-small cell lung cancer 
    Anderson, Ronald; Blidner, Ada Gabriela; Rapoport, Bernardo Leon (MDPI, 2021-06-08)
    Lung cancer remains the leading cause of cancer mortality in the United States, with non-small cell lung cancer (NSCLC) accounting for around 85% of cases. Of particular concern is the poor responsiveness of this malignancy ...
  • The role of transforming growth factor beta-1 in the progression of HIV/AIDS and development of non-AIDS-defining fibrotic disorders 
    Theron, Annette J.; Anderson, Ronald; Rossouw, Theresa M.; Steel, Helen C. (Frontiers Research Foundation, 2017-11-02)
    Even after attainment of sustained viral suppression following implementation of highly active antiretroviral therapy, HIV-infected persons continue to experience persistent, low-grade, systemic inflammation. Among other ...
  • Systemic levels of the soluble co-inhibitory immune checkpoints, CTLA-4, LAG-3, PD-1/PD-L1 and TIM-3 are markedly increased in basal cell carcinoma 
    Malinga, Nonkululeko Z.; Siwele, Shalate C.; Steel, Helen C.; Kwofie, Luyanda Laura Illicia; Meyer, Pieter Willem Adriaan; Smit, Teresa; Anderson, Ronald; Rapoport, Bernardo Leon; Kgokolo, C.M. (Elsevier, 2022-05)
    Although co-inhibitory immune checkpoint proteins are primarily involved in promoting cell-cell interactions that suppress adaptive immunity, especially tumor immunity, the soluble cell-free variants of these molecules ...