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Browsing by Author "Birkholtz, Lyn-Marie"
Now showing items 21-40 of 83
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Coetzee, Nanika; Von Gruning, Hilde; Opperman, Daniel; Van der Watt, Mariette Elizabeth; Reader, Janette; Birkholtz, Lyn-Marie (Nature Publishing Group, 2020-02-11)The epigenome of the malaria parasite, Plasmodium falciparum, is associated with regulation of various essential processes in the parasite including control of proliferation during asexual development as well as control ...
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Birkholtz, Lyn-Marie; Van Brummelen, A.C. (Anna Catharina); Clark, Katherine; Niemand, Jandeli; Marechal, Eric; Llinas, M.; Louw, Abraham Izak (Elsevier, 2008-02)Functional genomics approaches are indispensable tools in the drug discovery arena and have recently attained increased attention in antibacterial drug discovery research. However, the application of functional genomics ...
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Reeksting, S.B. (Shaun Bernard); Muller, Ingrid B.; Burger, Pieter Buys; Burgos, Emmanuel S.; Salmon, Laurent; Louw, Abraham Izak; Birkholtz, Lyn-Marie; Wrenger, Carsten (Portland Press on behalf of the Biochemical Society, 2013)Malaria tropica is a devastating infectious disease caused by Plasmodium falciparum. This parasite synthesizes vitamin B6 de novo via the pyridoxal 5-phosphate (PLP) synthase enzymatic complex consisting of PfPdx1 and ...
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Coertzen, Dina; Reader, Janette; Van der Watt, Mariette Elizabeth; Leshabane, Meta Kgaogelo; Langeveld, Henrico; Cheuka, Peter M.; Dziwornu, Godwin Akpeko; Chibale, Kelly; Birkholtz, Lyn-Marie (Taylor and Francis, 2021)The effectiveness of current antimalarial therapies that cure patients of the pathogenic asexual blood stages is rapidly declining due to the spread of antimalarial drug resistance. This requires the development of novel ...
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Fortuin, Lisa; Leshabane, Meta Kgaogelo; Pfukwa, Rueben; Coertzen, Dina; Birkholtz, Lyn-Marie; Klumperman, Bert (American Chemical Society, 2020-10)A facile synthetic methodology has been developed to prepare multifaceted polymeric prodrugs that are targeted, biodegradable, and nontoxic, and used for the delivery of combination therapy. This is the first instance of ...
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Birkholtz, Lyn-Marie (University of Pretoria, 2002)Malaria remains one of the most serious tropical infectious diseases affecting mankind. The prevention of the disease is hampered by the increasing resistance of the parasite to existing chemotherapies. The need for novel ...
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Clark, Katherine; Niemand, Jandeli; Reeksting, S.B. (Shaun Bernard); Smit, Salome; Van Brummelen, A.C. (Anna Catharina); Williams, Marni; Louw, Abraham Izak; Birkholtz, Lyn-Marie (Springer, 2010-02)Inhibition of polyamine biosynthesis and/or the perturbation of polyamine functionality have been exploited with success against parasitic diseases such as Trypanosoma infections. However, when the classical polyamine ...
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Connacher, Jessica I.; Josling, Gabrielle A.; Orchard, Lindsey M.; Reader, Janette; Llinas, Manuel; Birkholtz, Lyn-Marie (BMC, 2021-04)BACKGROUND : The Plasmodium sexual gametocyte stages are the only transmissible form of the malaria parasite and are thus responsible for the continued transmission of the disease. Gametocytes undergo extensive functional ...
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Birkholtz, Lyn-Marie; Blatch, Gregory; Coetzer, Theresa L.; Hoppe, Heinrich C.; Human, Esmare; Morris, Elizabeth J.; Ngcete, Zoleka; Oldfield, Lyndon; Roth, Robyn; Shonhai, Addmore; Stephens, Linda L.; Louw, Abraham Izak (BioMed Central, 2008)Malaria remains the world's most devastating tropical infectious disease with as many as 40% of the world population living in risk areas. The widespread resistance of Plasmodium parasites to the cost-effective chloroquine ...
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Van Biljon, Riette Andele; Van Wyk, Roelof Daniel Jacobus; Painter, Heather J.; Orchard, Lindsey; Reader, Janette; Niemand, Jandeli; Llinas, Manuel; Birkholtz, Lyn-Marie (BioMed Central, 2019-12)BACKGROUND : Malaria pathogenesis relies on sexual gametocyte forms of the malaria parasite to be transmitted between the infected human and the mosquito host but the molecular mechanisms controlling gametocytogenesis ...
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Raman, Jaishree; Gast, Laura; Balawanth, Ryleen; Tessema, Sofonias; Brooke, Basil; Maharaj, Rajendra; Munhenga, Givemore; Tshikae, Power; Lakan, Vishan; Mwamba, Tshiama; Makowa, Hazel; Sangweni, Lindi; Mkhabela, Moses; Zondo, Nompumelelo; Mohulatsi, Ernest; Nyawo, Zuziwe; Ngxongo, Sifiso; Msimang, Sipho; Dagata, Nicole; Greenhouse, Bryan; Birkholtz, Lyn-Marie; Shirreff, George; Graffy, Rebecca; Qwabe, Bheki; Moonasar, Devanand (BioMed Central, 2020-04-15)BACKGROUND : KwaZulu-Natal, one of South Africa’s three malaria endemic provinces, is nearing malaria elimination, reporting fewer than 100 locally-acquired cases annually since 2010. Despite sustained implementation of ...
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Connacher, Jessica I.; Von Gruning, Hilde; Birkholtz, Lyn-Marie (Frontiers Media S.A., 2022-04-01)Plasmodium falciparum remains the deadliest parasite species in the world, responsible for 229 million cases of human malaria in 2019. The ability of the P. falciparum parasite to progress through multiple life cycle ...
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Morahan, Belinda J.; Abrie, Clarissa; Al-Hasani, Keith; Batty, Mitchell B.; Corey, Victoria; Cowell, Anne N.; Niemand, Jandeli; Winzeler, Elizabeth A.; Birkholtz, Lyn-Marie; Doerig, Christian; Garcia-Bustos, Jose F. (Nature Research, 2020-11)Mitosis has been validated by numerous anti-cancer drugs as being a druggable process, and selective inhibition of parasite proliferation provides an obvious opportunity for therapeutic intervention against malaria. ...
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Mianda, S.M.; Invernizzi, Luke; Van der Watt, Mariette Elizabeth; Reader, Janette; Moyo, Phanankosi; Birkholtz, Lyn-Marie; Maharaj, Vinesh J. (Elsevier, 2022-10)Please abstract in the article.
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Moyo, Phanankosi; Botha, M.E. (Mariette); Nondaba, Sindisiwe; Niemand, Jandeli; Maharaj, Vinesh J.; Eloff, Jacobus Nicolaas; Louw, Abraham Izak; Birkholtz, Lyn-Marie (Elsevier, 2016-06)ETHNOPHARMACOLOGICAL RELEVANCE : Extracts of plant species, used traditionally to treat malaria, have been extensively investigated for their activity against Plasmodium intraerythrocytic asexual parasites in search ...
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Van Biljon, Riette Andele; Niemand, Jandeli; Clark, Katherine; Verlinden, Bianca K.; Abrie, Clarissa; Von Gruning, Hilde; Smidt, Werner; Smit, Annel; Reader, Janette; Painter, Heather; Llinas, Manuel; Doerig, Christian; Birkholtz, Lyn-Marie (Nature Publishing Group, 2018-11-08)The life cycle of the malaria parasite Plasmodium falciparum is tightly regulated, oscillating between stages of intense proliferation and quiescence. Cyclic 48-hour asexual replication of Plasmodium is markedly different ...
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Camara, Djeneb; Bisanz, Cordelia; Barette, Caroline; Van Daele, Jeroen; Human, Esmare; Barnard, Bernice; Van der Straeten, Dominique; Stove, Christophe P.; Lambert, Willy E.; Douce, Roland; Marechal, Eric; Birkholtz, Lyn-Marie; Cesbron-Delauw, Marie-France; Dumas, Renaud; Rebeille, Fabrice (American Society for Biochemistry and Molecular Biology, 2012-05)BACKGROUND: pABA biosynthesis is a potential target for antifolate drugs. RESULTS: Rubreserine inhibits GAT-ADCS, an enzyme involved in pABA biosynthesis, and decreased the folate content in Arabidopsis and Toxoplasma. ...
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Birkholtz, Lyn-Marie; Bastien, Olivier; Wells, Gordon; Grando, Delphine; Joubert, Fourie; Kasam, Vinod; Zimmermann, Marc; Ortet, Philippe; Jacq, Nicolas; Saidani, Nadia; Roy, Sylvaine; Hofmann-Apitius, Martin; Breton, Vincent; Louw, Abraham Izak; Marechal, Eric (BioMed Central, 2006-11)The organization and mining of malaria genomic and post-genomic data is important to significantly increase the knowledge of the biology of its causative agents, and is motivated, on a longer term, by the necessity to ...
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Verlinden, Bianca K.; De Beer, Marna; Pachaiyappan, Boobalan; Besaans, Ethan Wade; Anday, Warren A.; Reader, Janette; Niemand, Jandeli; Van Biljon, Riette Andele; Guy, Kiplin; Egan, Timothy; Woster, Patrick M.; Birkholtz, Lyn-Marie (Elsevier, 2015-08)A new series of potent potent aryl/alkylated (bis)urea- and (bis)thiourea polyamine analogues were synthesized and evaluated in vitro for their antiplasmodial activity. Altering the carbon backbone and terminal substituents ...
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Van Heerden, Ashleigh; Turon, Gemma; Duran-Frigola, Miquel; Pillay, Nelishia; Birkholtz, Lyn-Marie (American Chemical Society, 2023-11-07)Efficacy data from diverse chemical libraries, screened against the various stages of the malaria parasite Plasmodium falciparum, including asexual blood stage (ABS) parasites and transmissible gametocytes, serve as a ...
Now showing items 21-40 of 83