A biomimetic approach to the synthesis of a mycolic acid motif
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Date
Authors
Driver, Kathy (Cathryn Helena Stanford)
Balogun, Mohammed Olusegun
Toschi, Gianna
Baird, Mark S.
Pilcher, Lynne A.
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
A new method for the stereoselective synthesis of the (R,R)-b-hydroxy-a-alkyl fatty acid fragment of
mycolic acids, via an asymmetric anti-aldol reaction is reported. The ‘mycolic acid motif’ fragment was prepared in three steps and >98% ee.
Description
Keywords
Mycolic acid motif, Asymmetric anti-aldol reaction
Sustainable Development Goals
Citation
Driver, C. H. S.; et al. A biomimetic approach to the synthesis of a mycolic motif, Tetrahedron Letters, vol. 51, no. 8, pp. 1185-1186 (2010), doi:10.1016/j.tetlet.2009.12.105