Caseahomopene A, a ring-expanded homotriterpenoid from Casearia kurzii showing anti-inflammatory activities in vitro and in vivo

dc.contributor.authorAn, Lijun
dc.contributor.authorMa, Jun
dc.contributor.authorYang, Xueyuan
dc.contributor.authorLiang, Yue
dc.contributor.authorWang, Huimei
dc.contributor.authorTuerhong, Muhetaer
dc.contributor.authorLall, Namrita
dc.contributor.authorAbudukeremu, Munira
dc.contributor.authorZhang, Yi
dc.contributor.authorLee, Dongho
dc.contributor.authorXu, Jing
dc.contributor.authorWu, Xiaohui
dc.contributor.authorGuo, Yuanqiang
dc.date.accessioned2021-02-26T09:02:09Z
dc.date.issued2020-05
dc.description.abstractCaseahomopene A (1), a rare natural product with a ring-expanded homotriterpenoid skeleton, was isolated from the leaves of Casearia kurzii. The structure including the absolute configuration was determined by spectroscopic data and X-ray crystallography analysis. Compound 1 showed anti-inflammatory effects in vitro and in vivo using LPS-stimulated cell and zebrafish model. As a potential anti-inflammatory agent, the anti-inflammatory mechanism of 1 was also investigated.en_ZA
dc.description.departmentPlant Production and Soil Scienceen_ZA
dc.description.embargo2021-05-01
dc.description.librarianhj2021en_ZA
dc.description.sponsorshipThe National Key Research and Development Program of China, the National Natural Science Foundation of China, the Natural Science Foundation of Tianjin, China, Hundred Young Academic Leaders Program of Nankai University, and State Key Laboratory of Bioactive Substance and Function of Natural Medicines (Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College).en_ZA
dc.description.urihttp://www.elsevier.com/ locate/bmclen_ZA
dc.identifier.citationAn, L., Ma, J., Yang, X. et al. 2020, 'Caseahomopene A, a ring-expanded homotriterpenoid from Casearia kurzii showing anti-inflammatory activities in vitro and in vivo', Bioorganic Chemistry, vol. 98, art. 103758, pp. 1-7.en_ZA
dc.identifier.issn0045-2068
dc.identifier.other10.1016/j.bioorg.2020.103758
dc.identifier.urihttp://hdl.handle.net/2263/78860
dc.language.isoenen_ZA
dc.publisherElsevieren_ZA
dc.rights© 2020 Elsevier Inc. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Bioorganic Chemistry. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Bioorganic Chemistry, vol. 98, art. 103758, pp. 1-7, 2020. doi : 10.1016/j.bioorg.2020.103758.en_ZA
dc.subjectHomotriterpenoiden_ZA
dc.subjectAnti-inflammationen_ZA
dc.subjectZebrafish modelen_ZA
dc.subjectMolecular dockingen_ZA
dc.subjectCasearia kurziien_ZA
dc.titleCaseahomopene A, a ring-expanded homotriterpenoid from Casearia kurzii showing anti-inflammatory activities in vitro and in vivoen_ZA
dc.typePostprint Articleen_ZA

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