Caseahomopene A, a ring-expanded homotriterpenoid from Casearia kurzii showing anti-inflammatory activities in vitro and in vivo
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Date
Authors
An, Lijun
Ma, Jun
Yang, Xueyuan
Liang, Yue
Wang, Huimei
Tuerhong, Muhetaer
Lall, Namrita
Abudukeremu, Munira
Zhang, Yi
Lee, Dongho
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Caseahomopene A (1), a rare natural product with a ring-expanded homotriterpenoid skeleton, was isolated from the leaves of Casearia kurzii. The structure including the absolute configuration was determined by spectroscopic data and X-ray crystallography analysis. Compound 1 showed anti-inflammatory effects in vitro and in vivo using LPS-stimulated cell and zebrafish model. As a potential anti-inflammatory agent, the anti-inflammatory mechanism of 1 was also investigated.
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Keywords
Homotriterpenoid, Anti-inflammation, Zebrafish model, Molecular docking, Casearia kurzii
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Citation
An, L., Ma, J., Yang, X. et al. 2020, 'Caseahomopene A, a ring-expanded homotriterpenoid from Casearia kurzii showing anti-inflammatory activities in vitro and in vivo', Bioorganic Chemistry, vol. 98, art. 103758, pp. 1-7.