Safety evaluation of the single-dose Ad26. COV2.S vaccine among healthcare workers in the Sisonke study in South Africa : a phase 3b implementation trial

dc.contributor.authorTakuva, Simbarashe G.
dc.contributor.authorTakalani, Azwidhwi
dc.contributor.authorSeocharan, shen
dc.contributor.authorYende-Zuma, Nonhlanhla
dc.contributor.authorReddy, Tarylee
dc.contributor.authorEngelbrecht, Imke
dc.contributor.authorFaesen, Mark
dc.contributor.authorKhuto, Kentse
dc.contributor.authorWhyte, Carmen J.
dc.contributor.authorBailey, Veronique
dc.contributor.authorTrivella, Valentina
dc.contributor.authorPeter, Jonathan
dc.contributor.authorOpie, Jessica
dc.contributor.authorLouw, Vernon
dc.contributor.authorRowji, Pradeep
dc.contributor.authorJacobson, Barry
dc.contributor.authorGroenewald, Pamela
dc.contributor.authorDorrington, Rob E.
dc.contributor.authorLaubscher, Ria
dc.contributor.authorBradshaw, Debbie
dc.contributor.authorMoultrie, Harry
dc.contributor.authorFairall, Lara
dc.contributor.authorSanne, Ian
dc.contributor.authorGailBekker, Linda
dc.contributor.authorGray, Glenda
dc.contributor.authorGoga, Ameena Ebrahim
dc.contributor.authorGarrett, Nigel
dc.date.accessioned2022-11-02T11:55:06Z
dc.date.available2022-11-02T11:55:06Z
dc.date.issued2022-06-21
dc.description.abstractReal-world evaluation of the safety profile of vaccines after licensure is crucial to accurately characterise safety beyond clinical trials, support continued use, and thereby improve public confidence. The Sisonke study aimed to assess the safety and effectiveness of the Janssen Ad26.COV2.S vaccine among healthcare workers (HCWs) in South Africa. Here, we present the safety data.en_US
dc.description.departmentPaediatrics and Child Healthen_US
dc.description.departmentSchool of Health Systems and Public Health (SHSPH)en_US
dc.description.librariandm2022en_US
dc.description.sponsorshipFunding for the Sisonke Study was provided by: The National Department of Health through baseline funding to the South African Medical Research Council; the Solidarity Response Fund NPC; The Michael & Susan Dell Foundation; the ELMA Vaccines and Immunization Foundation; the ELMA Vaccines and Immunization Foundation; and the Bill & Melinda Gates Foundation.en_US
dc.description.urihttps://journals.plos.org/plosmedicineen_US
dc.identifier.citationTakuva, S., Takalani, A., Seocharan, I., Yende-Zuma, N., Reddy, T., Engelbrecht, I. et al. (2022) Safety evaluation of the single-dose Ad26.COV2.S vaccine among healthcare workers in the Sisonke study in South Africa: A phase 3b implementation trial. PLoS Medicine 19(6): e1004024. https://doi.org/10.1371/journal.pmed.1004024.en_US
dc.identifier.issn1549-1676 (online)
dc.identifier.issn1549-1277 (print)
dc.identifier.other10.1371/journal.pmed.1004024
dc.identifier.urihttps://repository.up.ac.za/handle/2263/88106
dc.language.isoenen_US
dc.publisherPublic Library Scienceen_US
dc.rights© 2022 Takuva et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.en_US
dc.subjectSafetyen_US
dc.subjectEffectivenessen_US
dc.subjectVaccinesen_US
dc.subjectJanssen Ad26.COV2.S vaccineen_US
dc.subjectHealthcare workers (HCW)en_US
dc.subjectSouth Africa (SA)en_US
dc.titleSafety evaluation of the single-dose Ad26. COV2.S vaccine among healthcare workers in the Sisonke study in South Africa : a phase 3b implementation trialen_US
dc.typeArticleen_US

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