Increased risk of suicide in schizophrenia patients with linkage to chromosome 13q

dc.contributor.authorMalherbe, P.J.
dc.contributor.authorKarayiorgou, M.
dc.contributor.authorEhlers, Rene
dc.contributor.authorRoos, J.L. (Johannes Louw)
dc.date.accessioned2017-03-07T05:28:38Z
dc.date.issued2017-05
dc.description.abstractWe link schizophrenia in families from the genetically isolated South African Afrikaner population to chromosome 13q (n =51), 1p (n =23) and combined 13q & 1p (n =18). Patients with linkages to chromosome 13q were 4.16 times more likely to meet diagnostic criteria for schizoaffective disorder compared to patients with linkage to 1p. A third of patients with linkage to both 13q & 1p met diagnostic criteria for SAD. There was a significant positive relationship between suicidality and a diagnosis of schizoaffective disorder. Identifying linkage to chromosome 13q may be informative in identifying suicide risk early and prevent morbidity and mortality in schizophrenia patients.en_ZA
dc.description.departmentPsychiatryen_ZA
dc.description.departmentStatisticsen_ZA
dc.description.embargo2018-05-31
dc.description.librarianhb2017en_ZA
dc.description.sponsorshipJL Roos is receiving incentive funding from the National Research Foundation (NRF).en_ZA
dc.description.urihttp://www.elsevier.com/locate/psychresen_ZA
dc.identifier.citationMalherbe, PJ, Karayiorgou, M, Ehlers, R & Roos, JL 2017, 'Increased risk of suicide in schizophrenia patients with linkage to chromosome 13q', Psychiatry Research, vol. 251, pp. 34-35.en_ZA
dc.identifier.issn0165-1781 (print)
dc.identifier.issn1872-7123 (online)
dc.identifier.other10.1016/j.psychres.2017.02.008
dc.identifier.urihttp://hdl.handle.net/2263/59286
dc.language.isoenen_ZA
dc.publisherElsevieren_ZA
dc.rights© 2017 Elsevier B.V. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Psychiatry Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Psychiatry Research, vol. 251, pp. 34-35, 2017. doi : 10.1016/j.psychres.2017.02.008.en_ZA
dc.subjectSchizoaffective disorderen_ZA
dc.subjectLinkage to chromosome 13qen_ZA
dc.subjectSuicideen_ZA
dc.subjectSchizophrenia (SCZ)en_ZA
dc.titleIncreased risk of suicide in schizophrenia patients with linkage to chromosome 13qen_ZA
dc.typePostprint Articleen_ZA

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