Increased risk of suicide in schizophrenia patients with linkage to chromosome 13q
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Date
Authors
Malherbe, P.J.
Karayiorgou, M.
Ehlers, Rene
Roos, J.L. (Johannes Louw)
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
We link schizophrenia in families from the genetically isolated South African Afrikaner population to
chromosome 13q (n =51), 1p (n =23) and combined 13q & 1p (n =18). Patients with linkages to chromosome
13q were 4.16 times more likely to meet diagnostic criteria for schizoaffective disorder compared to patients
with linkage to 1p. A third of patients with linkage to both 13q & 1p met diagnostic criteria for SAD. There was a
significant positive relationship between suicidality and a diagnosis of schizoaffective disorder. Identifying
linkage to chromosome 13q may be informative in identifying suicide risk early and prevent morbidity and
mortality in schizophrenia patients.
Description
Keywords
Schizoaffective disorder, Linkage to chromosome 13q, Suicide, Schizophrenia (SCZ)
Sustainable Development Goals
Citation
Malherbe, PJ, Karayiorgou, M, Ehlers, R & Roos, JL 2017, 'Increased risk of suicide in schizophrenia patients with linkage to chromosome 13q', Psychiatry Research, vol. 251, pp. 34-35.