Increased risk of suicide in schizophrenia patients with linkage to chromosome 13q

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Authors

Malherbe, P.J.
Karayiorgou, M.
Ehlers, Rene
Roos, J.L. (Johannes Louw)

Journal Title

Journal ISSN

Volume Title

Publisher

Elsevier

Abstract

We link schizophrenia in families from the genetically isolated South African Afrikaner population to chromosome 13q (n =51), 1p (n =23) and combined 13q & 1p (n =18). Patients with linkages to chromosome 13q were 4.16 times more likely to meet diagnostic criteria for schizoaffective disorder compared to patients with linkage to 1p. A third of patients with linkage to both 13q & 1p met diagnostic criteria for SAD. There was a significant positive relationship between suicidality and a diagnosis of schizoaffective disorder. Identifying linkage to chromosome 13q may be informative in identifying suicide risk early and prevent morbidity and mortality in schizophrenia patients.

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Keywords

Schizoaffective disorder, Linkage to chromosome 13q, Suicide, Schizophrenia (SCZ)

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Citation

Malherbe, PJ, Karayiorgou, M, Ehlers, R & Roos, JL 2017, 'Increased risk of suicide in schizophrenia patients with linkage to chromosome 13q', Psychiatry Research, vol. 251, pp. 34-35.