The burden of non-communicable diseases among people living with HIV in Sub-Saharan Africa : a systematic review and meta-analysis
Loading...
Date
Authors
Moyo-Chilufya, Maureen
Maluleke, Kuhlula
Kgarosi, Kabelo
Muyoyeta, Monde
Hongoro, Charles
Musekiwa, Alfred
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
BACKGROUND : Non-communicable diseases (NCDs) are increasing among people living with HIV (PLHIV), especially in
Sub-Saharan Africa (SSA). We determined the prevalence of NCDs and NCD risk factors among PLHIV in SSA to
inform health policy makers.
METHODS : We conducted a systematic review and meta-analysis on the prevalence of NCDs and risk factors among
PLHIV in SSA. We comprehensively searched PubMed/MEDLINE, Scopus, and EBSCOhost (CINAHL) electronic
databases for sources published from 2010 to July 2023. We applied the random effects meta-analysis model to
pool the results using STATA. The systematic review protocol was registered on PROSPERO (registration
number: CRD42021258769).
FINDINGS : We included 188 studies from 21 countries in this meta-analysis. Our findings indicate pooled prevalence
estimates for hypertension (20.1% [95% CI:17.5–22.7]), depression (30.4% [25.3–35.4]), diabetes (5.4% [4.4–6.4]),
cervical cancer (1.5% [0.1–2.9]), chronic respiratory diseases (7.1% [4.0–10.3]), overweight/obesity (32.2%
[29.7–34.7]), hypercholesterolemia (21.3% [16.6–26.0]), metabolic syndrome (23.9% [19.5–28.7]), alcohol
consumption (21.3% [17.9–24.6]), and smoking (6.4% [5.2–7.7]).
INTERPRETATION : People living with HIV have a high prevalence of NCDs and their risk factors including hypertension,
depression, overweight/obesity, hypercholesterolemia, metabolic syndrome and alcohol consumption. We recommend
strengthening of health systems to allow for improved integration of NCDs and HIV services in public health
facilities in SSA. NCD risk factors such as obesity, hypercholesterolemia, and alcohol consumption can be addressed
through health promotion campaigns. There is a need for further research on the burden of NCDs among PLHIV in
most of SSA.
Description
DATA SHARING STATEMENT : Data will be made available upon reasonable request.
Keywords
HIV/AIDS, Systematic review, Meta-analysis, Non-communicable diseases (NCDs), People living with HIV (PLHIV), Sub-Saharan Africa (SSA), Human immunodeficiency virus (HIV), Acquired immune deficiency syndrome (AIDS), SDG-03: Good health and well-being
Sustainable Development Goals
SDG-03:Good heatlh and well-being
Citation
Moyo-Chilufya, M., Maluleke, K., Kgarosi, K. 2023, 'The burden of non-communicable diseases among people living with HIV in Sub-Saharan Africa : a systematic review and meta-analysis', EClinicalMedicine, vol. 65, no. 102255, pp. 1-26. https://DOI.org/10.1016/j.eclinm.2023.102255.