Dammarane-type triterpenoids with anti-cancer activity from the leaves of Cleome gynandra

dc.contributor.authorMzondo, Buntubonke
dc.contributor.authorDlamini, Nomusa
dc.contributor.authorMalan, F.P. (Frederick)
dc.contributor.authorLabuschagne, Philip
dc.contributor.authorBovilla, Venugopal R.
dc.contributor.authorMadhunapantula, SubbaRao V.
dc.contributor.authorMaharaj, Vinesh J.
dc.contributor.emailvinesh.maharaj@up.ac.zaen_US
dc.date.accessioned2022-08-05T11:27:06Z
dc.date.issued2021-06
dc.description.abstractThree dammarane-type triterpernoids including two new ones, cleogynones A and B (1 and 2), were isolated from the leaves of Cleome gynandra. The structures of the new triterpenoids were elucidated by spectroscopic data analysis and confirmed by single crystal X-ray crystallography. All three compounds showed moderate cytotoxicity against breast cancer (MDA-MB-468), cleogynone B (2) and compound (3) further showed cytotoxicity against colorectal cancer (HCT-116 & HCT-15). Cleogynone B was also moderately active against lung cancer (A549).en_US
dc.description.departmentChemistryen_US
dc.description.embargo2023-03-08
dc.description.librarianhj2022en_US
dc.description.sponsorshipThe National Research Foundation and the Department of Science and Innovation in collaboration with the Council for Scientific and Industrial Research, South Africa and the University of Pretoria.en_US
dc.description.urihttps://www.elsevier.com/locate/phytolen_US
dc.identifier.citationMzondo, B., Dlamini, N., Malan, F.P. et al. 2021, 'Dammarane-type triterpenoids with anti-cancer activity from the leaves of Cleome gynandra', Phytochemistry Letters, vol. 43, pp. 16-22, doi : 10.1016/j.phytol.2021.03.001.en_US
dc.identifier.issn1874-3900 (print)
dc.identifier.issn1876-7486 (online)
dc.identifier.other10.1016/j.phytol.2021.03.001
dc.identifier.urihttps://repository.up.ac.za/handle/2263/86723
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rights© 2021 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Phytochemistry Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Phytochemistry Letters, vol. 43, pp. 16-22, 2021. doi : 10.1016/j.phytol.2021.03.001.en_US
dc.subjectCleome gynandraen_US
dc.subjectDammarane triterpernoidsen_US
dc.subjectLung canceren_US
dc.subjectBreast canceren_US
dc.subjectColorectal cancer (CRC)en_US
dc.titleDammarane-type triterpenoids with anti-cancer activity from the leaves of Cleome gynandraen_US
dc.typePostprint Articleen_US

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