Dammarane-type triterpenoids with anti-cancer activity from the leaves of Cleome gynandra
Loading...
Date
Authors
Mzondo, Buntubonke
Dlamini, Nomusa
Malan, F.P. (Frederick)
Labuschagne, Philip
Bovilla, Venugopal R.
Madhunapantula, SubbaRao V.
Maharaj, Vinesh J.
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Three dammarane-type triterpernoids including two new ones, cleogynones A and B (1 and 2), were isolated from the leaves of Cleome gynandra. The structures of the new triterpenoids were elucidated by spectroscopic data analysis and confirmed by single crystal X-ray crystallography. All three compounds showed moderate cytotoxicity against breast cancer (MDA-MB-468), cleogynone B (2) and compound (3) further showed cytotoxicity against colorectal cancer (HCT-116 & HCT-15). Cleogynone B was also moderately active against lung cancer (A549).
Description
Keywords
Cleome gynandra, Dammarane triterpernoids, Lung cancer, Breast cancer, Colorectal cancer (CRC)
Sustainable Development Goals
Citation
Mzondo, B., Dlamini, N., Malan, F.P. et al. 2021, 'Dammarane-type triterpenoids with anti-cancer activity from the leaves of Cleome gynandra', Phytochemistry Letters, vol. 43, pp. 16-22, doi : 10.1016/j.phytol.2021.03.001.