Comparative aspects of immunity and vaccination in human and bovine trichomoniasis : a review

dc.contributor.authorChapwanya, Aspinas
dc.contributor.authorUsman, Abubakar Yusha’u
dc.contributor.authorIrons, Pete Charles
dc.date.accessioned2015-11-13T06:08:21Z
dc.date.issued2016-01
dc.description.abstractTrichomonas vaginalis and Tritrichomonas foetus are important extracellular protozoans that cause, respectively, human and bovine venereal diseases. Trichomonads are extracellular parasites that primarily inhabit the genital tracts of the mammalian hosts where they overcome the mucus barrier and parasitize mucosa by contact-dependent or contact-independent cytotoxicity. Transient immunity is usually achieved by the host after clinical infection. At present, vaccination in cattle reduces infection rates and reproductive wastage in affected herds. After vaccination, immunoglobulin G (IgG) levels increase in systemic circulation while immunoglobulin A (IgA) levels rise in the vagina. Only moderate protection is conferred by means of vaccination. Future vaccine development strategies are needed for cattle to enhance the antigenic component or use adjuvant that strongly activates the innate immune response to produce safe and potent vaccines. This paper reviews the current knowledge of the immunology of trichomoniasis infection and the challenges and potential of vaccines in the control of the infection in human and bovine trichomoniasis.en_ZA
dc.description.embargo2017-01-30
dc.description.librarianhb2015en_ZA
dc.description.sponsorshipInstitute of Food, Nutrition and Well-being (IFNuW) from the University of Pretoria, South Africa.en_ZA
dc.description.urihttp://link.springer.com/journal/11250en_ZA
dc.identifier.citationChapwanya, A, Usman, AY & Irons, PC 2016, 'Comparative aspects of immunity and vaccination in human and bovine trichomoniasis', Tropical Animal Health and Production, vol. 48, no. 1, pp-1-7.en_ZA
dc.identifier.issn0049-4747 (print)
dc.identifier.issn1573-7438 (online)
dc.identifier.other10.1007/s11250-015-0909-1
dc.identifier.other6603165622
dc.identifier.otherO-6401-2014
dc.identifier.urihttp://hdl.handle.net/2263/50444
dc.language.isoenen_ZA
dc.publisherSpringeren_ZA
dc.relation.requiresAdobe Acrobat Readeren
dc.rights© Springer Science+Business Media Dordrecht 2015. The original publication is available at : http://link.springer.comjournal/11250.en_ZA
dc.subjectTritrichomonas foetusen_ZA
dc.subjectTrichomonas vaginalisen_ZA
dc.subjectVenereal infectionen_ZA
dc.subjectImmunityen_ZA
dc.subjectVaccinationen_ZA
dc.subjectBovineen_ZA
dc.subjectFertilityen_ZA
dc.subject.otherVeterinary science articles SDG-01en_ZA
dc.subject.otherVeterinary science articles SDG-03en_ZA
dc.subject.otherSDG-03: Good health and well-being
dc.subject.otherSDG-01: No poverty
dc.titleComparative aspects of immunity and vaccination in human and bovine trichomoniasis : a reviewen_ZA
dc.typePostprint Articleen_ZA

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