The treatment of cholesterol : issues, effects and targets

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Authors

Ker, James A.

Journal Title

Journal ISSN

Volume Title

Publisher

South African Academy of Family Practice/Primary Care

Abstract

Statins are the most powerful cholesterol lowering drugs currently available. Statins inhibit 3-hydroxy-3-methylglutaryl-coenzyme A (HMG CoA) reductase, which leads to reduced cholesterol synthesis. In addition, low-density cholesterol receptors on the hepatocyte surface are upregulated, leading to increased clearance of cholesterol. The end result is a significant reduction in cholesterol levels, and a consequent significant reduction in mortality and cardiovascular events in the appropriate individual.

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Keywords

Cholesterol, Hypercholesterolemia, Treatment, Drug therapy, Statins, Effectivity, LDL cholesterol, Target, Risk, Prevention, Elderly, Time factors, Atherosclerosis, Safety

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Citation

Ker, JA 2010, 'The treatment of cholesterol : issues, effects and targets', South African Family Practice, vol. 52, no. 6, pp. 523-524. [http;//www.safpj.co.za]