The treatment of cholesterol : issues, effects and targets
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Date
Authors
Ker, James A.
Journal Title
Journal ISSN
Volume Title
Publisher
South African Academy of Family Practice/Primary Care
Abstract
Statins are the most powerful cholesterol lowering drugs currently available. Statins inhibit 3-hydroxy-3-methylglutaryl-coenzyme A (HMG CoA) reductase, which leads to reduced cholesterol synthesis. In addition, low-density cholesterol receptors on the hepatocyte surface are upregulated, leading to increased clearance of cholesterol. The end result is a significant reduction in cholesterol levels, and a consequent significant reduction in mortality and cardiovascular events in the appropriate individual.
Description
Keywords
Cholesterol, Hypercholesterolemia, Treatment, Drug therapy, Statins, Effectivity, LDL cholesterol, Target, Risk, Prevention, Elderly, Time factors, Atherosclerosis, Safety
Sustainable Development Goals
Citation
Ker, JA 2010, 'The treatment of cholesterol : issues, effects and targets', South African Family Practice, vol. 52, no. 6, pp. 523-524. [http;//www.safpj.co.za]