Persistent Chlamydia trachomatis, Neisseria gonorrhoeae or Trichomonas vaginalis positivity after treatment among human immunodeficiency virus-infected pregnant women, South Africa

dc.contributor.authorMedina-Marino, Andrew
dc.contributor.authorMudau, Maanda
dc.contributor.authorKojima, Noah
dc.contributor.authorPeters, Remco P.H.
dc.contributor.authorFeucht, Ute Dagmar
dc.contributor.authorDe Vos, Lindsey
dc.contributor.authorOlivier, Dawie
dc.contributor.authorMuzny, Christina A.
dc.contributor.authorMcIntyre, James A.
dc.contributor.authorKlausner, Jeffrey D.
dc.date.accessioned2021-10-21T10:59:06Z
dc.date.available2021-10-21T10:59:06Z
dc.date.issued2020-03
dc.description.abstractThe objective of this study is to assess the predictors and frequency of persistent sexually transmitted infection (STI) positivity in human immunodeficiency virus (HIV)-infected pregnant women treated for Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) or Trichomonas vaginalis (TV) infection. We enrolled HIV-infected pregnant women attending their first antenatal care visit and tested them for urogenital CT, NG and TV infection using Xpert® CT/NG and TV assays (Cepheid, Sunnyvale, CA). Those testing positive were treated. Participants either notified partners to seek treatment or were given extra medication to deliver to partners for treatment. Repeat testing was conducted approximately 21 days post-treatment or treatment initiation. Among 427 participants, 172 (40.3%) tested positive for any STI. Of the 136 (79.1%) that returned for repeat testing, 36 (26.5%) tested positive for the same organism: CT = 27 (26.5%), NG = 1 (6.3%), TV = 11 (16.7%). Persistent CT positivity was independently associated with having more than one sex partner in the preceding 12 months (adjusted-prevalence ratio [aPR] = 3.03, 95% CI: 1.44–6.37) and being newly diagnosed with HIV infection during the first antenatal care visit compared to those currently on antiretroviral therapy (aPR = 3.97, 95% CI: 1.09–14.43). Persistent TV positivity was associated with not knowing if a partner sought treatment following STI disclosure (aPR = 12.6, 95% CI: 2.16–73.5) and prior diagnosis of HIV but not currently on antiretroviral therapy. (aPR = 4.14; 95% CI: 1.25–13.79). We identified a high proportion of HIV-infected pregnant women with persistent CT or TV positivity after treatment. To decrease the risk of re-infection, enhanced strategies for partner treatment programmes are needed to improve the effectiveness of STI screening and treatment in pregnancy. The relationship between not being on antiretroviral therapy and persistent STI positivity needs further study.en_ZA
dc.description.departmentMedical Microbiologyen_ZA
dc.description.departmentPaediatrics and Child Healthen_ZA
dc.description.librarianhj2021en_ZA
dc.description.sponsorshipThe Eunice Kennedy Shriver Institute of Child Health and Human Development, National Institutes of Health (NIH), award R21HD084274 and the President’s Emergency Plan for AIDS Relief through the United States Agency of the Cooperative Agreement AID 674-A-12-00017 funded this study. Noah Kojima was supported by the U.S. NIH Fogarty International Center (award number D43TW009343) and the University of California Global Health Institute. Christina A Muzny was supported by K23AI106957-01A1 from the National Institute of Allergy and Infectious Diseases.en_ZA
dc.description.urihttps://journals.sagepub.com/home/stden_ZA
dc.identifier.citationMedina-Marino A, Mudau M, Kojima N, et al. Persistent Chlamydia trachomatis, Neisseria gonorrhoeae or Trichomonas vaginalis positivity after treatment among human immunodeficiency virus-infected pregnant women, South Africa. International Journal of STD & AIDS. 2020;31(4):294-302. doi:10.1177/0956462419898612.en_ZA
dc.identifier.issn0956-4624 (print)
dc.identifier.issn1758-1052 (online)
dc.identifier.other10.1177/0956462419898612
dc.identifier.urihttp://hdl.handle.net/2263/82212
dc.language.isoenen_ZA
dc.publisherSageen_ZA
dc.rights© The Author(s) 2020. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License.en_ZA
dc.subjectGonorrhoea (Neisseria gonorrhoeae)en_ZA
dc.subjectScreeningen_ZA
dc.subjectChlamydia trachomatis (CT)en_ZA
dc.subjectTrichomonas vaginalis (TV)en_ZA
dc.subjectGonorrhoeaen_ZA
dc.subjectNeisseria gonorrhoeae (NG)en_ZA
dc.subjectSexually transmitted infection (STI)en_ZA
dc.subjectHuman immunodeficiency virus (HIV)en_ZA
dc.subjectPregnancyen_ZA
dc.titlePersistent Chlamydia trachomatis, Neisseria gonorrhoeae or Trichomonas vaginalis positivity after treatment among human immunodeficiency virus-infected pregnant women, South Africaen_ZA
dc.typeArticleen_ZA

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Medina_Persistent_2020.pdf
Size:
490.42 KB
Format:
Adobe Portable Document Format
Description:
Article

License bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
1.75 KB
Format:
Item-specific license agreed upon to submission
Description: