Preclinical assessment addressing intravenous administration of a [68Ga]Ga-PSMA-617 microemulsion : acute in vivo toxicity, tolerability, PET imaging, and biodistribution

dc.contributor.authorMandiwana, Vusani
dc.contributor.authorKalombo, Lonji
dc.contributor.authorHayeshi, Rose
dc.contributor.authorZeevaart, Jan Rijn
dc.contributor.authorEbenhan, Thomas
dc.date.accessioned2021-12-01T10:16:08Z
dc.date.available2021-12-01T10:16:08Z
dc.date.issued2021-04-30
dc.description.abstractIt has been herein presented that a microemulsion, known to be an effective and safe drug delivery system following intravenous administration, can be loaded with traces of [68Ga]Ga-PSMA- 617 without losing its properties or causing toxicity. Following tolerated IV injections the capability of the microemulsion in altering [68Ga]Ga-PSMA-617 distribution was presented at 120 min post injection based on its ex vivo biodistribution results.en_ZA
dc.description.departmentNuclear Medicineen_ZA
dc.description.librarianam2021en_ZA
dc.description.sponsorshipThe Nuclear Technologies in Medicine and the Biosciences Initiative (NTeMBI) is funded by the Department of Science and Technology, the Department of Nuclear Medicine, University of Pretoria and the Council for Scientific and Industrial Research and the Carl and Emily Fuchs Foundation.en_ZA
dc.description.urihttp://www.mdpi.com/journal/moleculesen_ZA
dc.identifier.citationMandiwana, V.; Kalombo, L.; Hayeshi, R.; Zeevaart, J.R.; Ebenhan, T. Preclinical Assessment Addressing Intravenous Administration of a [68Ga]Ga-PSMA-617 Microemulsion: Acute In Vivo Toxicity, Tolerability, PET Imaging, and Biodistribution. Molecules 2021, 26, 2650. https://DOI.org/ 10.3390/molecules26092650.en_ZA
dc.identifier.issn1420-3049 (print)
dc.identifier.issn1420-3049 (online)
dc.identifier.other10.3390/molecules26092650
dc.identifier.urihttp://hdl.handle.net/2263/82928
dc.language.isoenen_ZA
dc.publisherMDPI Publishingen_ZA
dc.rights© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.en_ZA
dc.subjectBiodistributionen_ZA
dc.subject68Gaen_ZA
dc.subject[68Ga]Ga-PSMA-617-MEen_ZA
dc.subjectIn vivoen_ZA
dc.subjectMicroemulsionen_ZA
dc.subjectMicroPET/CTen_ZA
dc.subjectProstate canceren_ZA
dc.subjectPSMA-617en_ZA
dc.subjectToxicityen_ZA
dc.titlePreclinical assessment addressing intravenous administration of a [68Ga]Ga-PSMA-617 microemulsion : acute in vivo toxicity, tolerability, PET imaging, and biodistributionen_ZA
dc.typeArticleen_ZA

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