Preclinical assessment addressing intravenous administration of a [68Ga]Ga-PSMA-617 microemulsion : acute in vivo toxicity, tolerability, PET imaging, and biodistribution
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Date
Authors
Mandiwana, Vusani
Kalombo, Lonji
Hayeshi, Rose
Zeevaart, Jan Rijn
Ebenhan, Thomas
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI Publishing
Abstract
It has been herein presented that a microemulsion, known to be an effective and safe drug
delivery system following intravenous administration, can be loaded with traces of [68Ga]Ga-PSMA-
617 without losing its properties or causing toxicity. Following tolerated IV injections the capability
of the microemulsion in altering [68Ga]Ga-PSMA-617 distribution was presented at 120 min post
injection based on its ex vivo biodistribution results.
Description
Keywords
Biodistribution, 68Ga, [68Ga]Ga-PSMA-617-ME, In vivo, Microemulsion, MicroPET/CT, Prostate cancer, PSMA-617, Toxicity
Sustainable Development Goals
Citation
Mandiwana, V.;
Kalombo, L.; Hayeshi, R.;
Zeevaart, J.R.; Ebenhan, T.
Preclinical Assessment Addressing
Intravenous Administration of a
[68Ga]Ga-PSMA-617 Microemulsion:
Acute In Vivo Toxicity, Tolerability,
PET Imaging, and Biodistribution.
Molecules 2021, 26, 2650. https://DOI.org/ 10.3390/molecules26092650.