Chemokines as possible therapeutic targets in metastatic melanoma
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Date
Authors
Basson, Charlise
Serem, June Cheptoo
Bipath, Priyesh
Hlophe, Y.
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley
Abstract
BACKGROUND : Cutaneous melanoma is a relentless form of cancer which continues to rise in incidence. Currently, cutaneous melanoma is the leading cause of skin cancer-related mortality, which can mainly be attributed to its metastatic potential. The activation of chemokine axes is a major contributor to melanoma metastasis through its involvement in promoting tumour cell migration, proliferation, survival, and adhesion. This review will focus on the role of chemokines in melanoma and possible therapeutic strategies to alter chemokine activation and subsequently inhibit the activation of signalling cascades that may promote metastasis.
METHODS : A literature review was conducted to evaluate chemokines as possible therapeutic targets in metastatic melanoma.
RESULTS : The crosstalk between signalling pathways and immune responses in the melanoma microenvironment resembles a complex and dynamic system. Therefore, the involvement of governing chemokine axes in the promotion of cutaneous and metastatic melanoma demands a proper understanding of the tumour microenvironment in order to identify possible targets and develop appropriate treatments against melanoma.
CONCLUSION : Even though chemokine axes are regarded as promising therapeutic targets, it has become increasingly evident that chemokines can play a critical role in both tumour inhibition and promotion. The inhibition of chemokine axes to inhibit signalling cascades in target cells that regulate metastasis should, therefore, be carefully approached.
Description
DATA AVAILABILITY STATEMENT : Data sharing not applicable to this article as no datasets were generated or analysed during the current study.
Keywords
Sustainable Development Goals
Citation
Basson, C., Serem, J.C., Bipath, P. & Hlophe, Y.N. Chemokines as possible therapeutic targets in metastatic melanoma. Cancer Medicine 2023; 12: 14387-14402. doi:10.1002/cam4.6055.