Klebsiella pneumoniae with carbapenemases : high prevalence of sequence type 307 with blaOXA181 in South African community hospitals

dc.contributor.authorSalvador-Oke, Kafilat Taiwo
dc.contributor.authorPitout, Johann D.D.
dc.contributor.authorPeirano, Gisele
dc.contributor.authorStrydom, Kathy-Anne
dc.contributor.authorKingsburgh, Chanel
dc.contributor.authorEhlers, Marthie Magdaleen
dc.contributor.authorKock, Marleen M.
dc.contributor.emailmarleen.kock@up.ac.zaen_US
dc.date.accessioned2024-10-22T06:34:07Z
dc.date.available2024-10-22T06:34:07Z
dc.date.issued2024-11
dc.descriptionDATA AVAILABILITY : No datasets were generated or analysed during the current study.en_US
dc.description.abstractThis study investigated the molecular characteristics of urinary carbapenemase-producing Klebsiella pneumoniae isolates (n = 194) in Gauteng, South Africa, using simple, cost-effective PCR methodologies. Extensively drug resistant (XDR) ST307 with blaOXA-181 on IncX3 plasmids was endemic in Gauteng community hospitals leaving limited options for treating in- and outpatient urinary tract infections. High-level ceftazidime/avibactam resistance was detected among isolates harbouring blaOXA-48-like including blaOXA-181. These findings highlighted the need for genomic methodologies suitable for lower- and middle-income countries to track XDR clones and plasmids in community hospitals. Such results will aid with treatment and stewardship strategies.en_US
dc.description.departmentMedical Microbiologyen_US
dc.description.librarianhj2024en_US
dc.description.sdgSDG-03:Good heatlh and well-beingen_US
dc.description.sponsorshipThe National Research Foundation (NRF) of South Africa; Competitive Support for Unrated Researchers and the University of Pretoria (PhD student bursary, 2022). Open access funding provided by University of Pretoria.en_US
dc.description.urihttps://link.springer.com/journal/10096en_US
dc.identifier.citationSalvador-Oke, K.T., Pitout, J.D.D., Peirano, G. et al. Klebsiella pneumoniae with carbapenemases: high prevalence of sequence type 307 with blaOXA181 in South African community hospitals. European Journal of Clinical Microbiology & Infectious Diseases 43, 2239–2244 (2024). https://doi.org/10.1007/s10096-024-04947-z.en_US
dc.identifier.issn0934-9723 (print)
dc.identifier.issn1435-4373 (online)
dc.identifier.other10.1007/s10096-024-04947-z
dc.identifier.urihttp://hdl.handle.net/2263/98695
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.rights© The Author(s) 2024. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License.en_US
dc.subjectKlebsiella pneumoniaeen_US
dc.subjectGauteng Province, South Africaen_US
dc.subjectExtensively drug resistant (XDR)en_US
dc.subjectCarbapenemase-producing Klebsiella pneumoniaeen_US
dc.subjectHigh-risk clone ST307en_US
dc.subjectIncX3 plasmiden_US
dc.subjectbla OXA-181en_US
dc.subjectLow- and middle-income countries (LMICs)en_US
dc.subjectSDG-03: Good health and well-beingen_US
dc.titleKlebsiella pneumoniae with carbapenemases : high prevalence of sequence type 307 with blaOXA181 in South African community hospitalsen_US
dc.typeArticleen_US

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