Klebsiella pneumoniae with carbapenemases : high prevalence of sequence type 307 with blaOXA181 in South African community hospitals
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Date
Authors
Salvador-Oke, Kafilat Taiwo
Pitout, Johann D.D.
Peirano, Gisele
Strydom, Kathy-Anne
Kingsburgh, Chanel
Ehlers, Marthie Magdaleen
Kock, Marleen M.
Journal Title
Journal ISSN
Volume Title
Publisher
Springer
Abstract
This study investigated the molecular characteristics of urinary carbapenemase-producing Klebsiella pneumoniae isolates (n = 194) in Gauteng, South Africa, using simple, cost-effective PCR methodologies. Extensively drug resistant (XDR) ST307 with blaOXA-181 on IncX3 plasmids was endemic in Gauteng community hospitals leaving limited options for treating in- and outpatient urinary tract infections. High-level ceftazidime/avibactam resistance was detected among isolates harbouring blaOXA-48-like including blaOXA-181. These findings highlighted the need for genomic methodologies suitable for lower- and middle-income countries to track XDR clones and plasmids in community hospitals. Such results will aid with treatment and stewardship strategies.
Description
DATA AVAILABILITY :
No datasets were generated or analysed during the current study.
Keywords
Klebsiella pneumoniae, Gauteng Province, South Africa, Extensively drug resistant (XDR), Carbapenemase-producing Klebsiella pneumoniae, High-risk clone ST307, IncX3 plasmid, bla OXA-181, Low- and middle-income countries (LMICs), SDG-03: Good health and well-being
Sustainable Development Goals
SDG-03:Good heatlh and well-being
Citation
Salvador-Oke, K.T., Pitout, J.D.D., Peirano, G. et al. Klebsiella pneumoniae with carbapenemases: high prevalence of sequence type 307 with blaOXA181 in South African community hospitals. European Journal of Clinical Microbiology & Infectious Diseases 43, 2239–2244 (2024). https://doi.org/10.1007/s10096-024-04947-z.