Successful treatment of disabling paroxysmal nonkinesigenic dyskinesia with deep brain stimulation of the globus pallidus internus

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Authors

Van Coller, Riaan
Slabbert, Pieter
Schutte, Clara-Maria

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Publisher

Karger

Abstract

Paroxysmal nonkinesigenic dyskinesia (PNKD) causes episodes of treatment-resistant involuntary movements. Previous case reports showed effective treatment of PNKD with deep brain stimulation (DBS). We report 2 patients in whom DBS was highly successful when other treatment modalities had failed. METHODS : Two patients aged 34 and 24 years with a longstanding history of PNKD were treated with globus pallidus internus (GPi) DBS. Motor effects were monitored and followed up postoperatively and again at 6 months after surgery. RESULTS : Both patients responded very well to GPi DBS with complete suppression of dyskinesia after surgery in 1 patient and in the second after an additional adjustment of stimulation. CONCLUSION : GPi DBS might be an effective alternative treatment modality for PNKD

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Keywords

Paroxysmal dyskinesia, Paroxysmal nonkinesigenic dyskinesia (PNKD), Deep brain stimulation (DBS), Globus pallidus internus (GPi)

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Citation

Van Coller, R, Slabbert, P, Vaidyanathan, J & Schutte, C 2014, 'Successful treatment of disabling paroxysmal nonkinesigenic dyskinesia with deep brain stimulation of the globus pallidus internus', Stereotactic and Functional Neurosurgery, vol. 92, no. 6, pp. 388-392.