Histological analysis of the effects of cadmium, chromium and mercury alone and in combination on the spleen of male Sprague-Dawley rats

dc.contributor.authorVenter, Chantelle
dc.contributor.authorOlivier, Anel
dc.contributor.authorTaute, Helena
dc.contributor.authorOberholzer, Hester Magdalena
dc.contributor.emailnanette.oberholzer@up.ac.zaen_ZA
dc.date.accessioned2020-10-07T10:37:04Z
dc.date.issued2020
dc.description.abstractThe mining sector in South Africa is expected to be the fifth largest in the world. Both mining and transport are the most common reasons for an increased risk of human exposure to heavy metal contamination in South Africa. Due to increasing amounts of metals in the environment, this study identified three metals cadmium, chromium and mercury based on the risk of exposure in South Africa. The aim of this study was to investigate the changes in the morphology of the spleen tissue of male Sprague-Dawley rats exposed to these metals alone and in combination by using light microscopy. Forty eight animals in eight experimental groups were exposed, via oral gavage, to these metals at 1000× the World Health Organization’s acceptable water limits of each respective metal, alone and in combination, for 28 days. Changes in the histological structure of the spleen were observed using haematoxylin and eosin and picrosirius red staining. Necrosis was observed in all the groups, with the severity varying between the different exposure groups, alone or in combination. Fibrosis in the spleen tissue was only seen in the experimental groups exposed to cadmium and mercury respectively, as well as in the combination of cadmium and mercury.en_ZA
dc.description.departmentAnatomyen_ZA
dc.description.embargo2021-05-18
dc.description.librarianhj2020en_ZA
dc.description.urihttp://www.tandfonline.com/loi/lesa20en_ZA
dc.identifier.citationVenter, C., Olivier, A., Taute, H. et al. 2020, 'Histological analysis of the effects of cadmium, chromium and mercury alone and in combination on the spleen of male Sprague-Dawley rats', Journal of Environmental Science and Health, Part A, vol. 55, no. 8, pp. 925-934, doi: 10.1080/10934529.2020.1756158.en_ZA
dc.identifier.issn1093-4529 (print)
dc.identifier.issn1532-4117 (online)
dc.identifier.other10.1080/10934529.2020.1756158
dc.identifier.urihttp://hdl.handle.net/2263/76382
dc.language.isoenen_ZA
dc.publisherTaylor and Francisen_ZA
dc.rights© 2020 Taylor & Francis Group, LLC. This is an electronic version of an article published in Journal of Environmental Science and Health, Part A: Toxic/Hazardous Substances and Environmental Engineering, Journal of Environmental Science and Health, Part A, vol. 55, no. 8, pp. 925-934, 2020. Journal of Environmental Science and Health, Part A: Toxic/Hazardous Substances and Environmental Engineering is available online at : http://www.tandfonline.com/loi/lesa20.en_ZA
dc.subjectFibrosisen_ZA
dc.subjectHeavy metalsen_ZA
dc.subjectToxicityen_ZA
dc.subjectSpleenen_ZA
dc.subjectLight microscopyen_ZA
dc.subjectMorphologyen_ZA
dc.subjectSprague-Dawley raten_ZA
dc.subject.otherHealth sciences articles SDG-03
dc.subject.otherSDG-03: Good health and well-being
dc.titleHistological analysis of the effects of cadmium, chromium and mercury alone and in combination on the spleen of male Sprague-Dawley ratsen_ZA
dc.typePostprint Articleen_ZA

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Venter_Histological_2020.pdf
Size:
2.39 MB
Format:
Adobe Portable Document Format
Description:
Postprint Article

License bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
1.75 KB
Format:
Item-specific license agreed upon to submission
Description: