A monovalent attenuated serotype 2 bluetongue virus vaccine confers homologous protection in sheep
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Date
Authors
Hunter, P.
Modumo, J.
Journal Title
Journal ISSN
Volume Title
Publisher
Published jointly by the Agricultural Research Council, ARC-Onderstepoort Veterinary Institute and the Faculty of Veterinary Science, University of Pretoria.
Abstract
An outbreak of bluetongue caused by bluetongue virus serotype 2 virus in certain Mediterranean countries during 1999/2000, presented an opportunity to produce a monovalent type 2 vaccine. Since no data have been published previously on the protection conferred by the current live attenuated bluetongue vaccine strains used in the polyvalent vaccine, a challenge experiment was performed to determine the degree of homologous protection induced by the type 2 vaccine strain. The standard vaccine dose of 5X10⁴ pfu of vaccine conferred 99.7% protection against clinical disease and no viraemia was detected in the vaccinates.
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Keywords
Veterinary medicine, Attenuated, Bluetongue vaccine, Mediterranean countries, Monovalent, Serotype 2
Sustainable Development Goals
Citation
Hunter, P & Modumo, J 2001, 'A monovalent attenuated serotype 2 bluetongue virus vaccine confers homologous protection in sheep’. Onderstepoort Journal of Veterinary Research, vol. 68, no. 4, pp. 331-333.