COVID-19 Is a multi-organ aggressor : epigenetic and clinical marks

dc.contributor.authorKgatle, Mankgopo
dc.contributor.authorLawal, Ismaheel Opeyemi
dc.contributor.authorMashabela, Gabriel
dc.contributor.authorBoshomane, Tebatso M.G.
dc.contributor.authorKoatale, Palesa Caroline
dc.contributor.authorMahasha, Phetole Walter
dc.contributor.authorNdlovu, Honest
dc.contributor.authorVorster, Mariza
dc.contributor.authorRodrigues, Hosana Gomes
dc.contributor.authorZeevaart, Jan Rijn
dc.contributor.authorGordon, Siamon
dc.contributor.authorMoura-Alves, Pedro
dc.contributor.authorSathekge, Mike Machaba
dc.contributor.emailmike.sathekge@up.ac.zaen_ZA
dc.date.accessioned2022-03-10T10:59:42Z
dc.date.available2022-03-10T10:59:42Z
dc.date.issued2021-10-08
dc.description.abstractThe progression of coronavirus disease 2019 (COVID-19), resulting from a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, may be influenced by both genetic and environmental factors. Several viruses hijack the host genome machinery for their own advantage and survival, and similar phenomena might occur upon SARS-CoV-2 infection. Severe cases of COVID-19 may be driven by metabolic and epigenetic driven mechanisms, including DNA methylation and histone/chromatin alterations. These epigenetic phenomena may respond to enhanced viral replication and mediate persistent long-term infection and clinical phenotypes associated with severe COVID-19 cases and fatalities. Understanding the epigenetic events involved, and their clinical significance, may provide novel insights valuable for the therapeutic control and management of the COVID- 19 pandemic. This review highlights different epigenetic marks potentially associated with COVID-19 development, clinical manifestation, and progression.en_ZA
dc.description.departmentNuclear Medicineen_ZA
dc.description.librarianam2022en_ZA
dc.description.urihttp://www.frontiersin.org/Immunologyen_ZA
dc.identifier.citationKgatle, M.M., Lawal, I.O., Mashabela, G., Boshomane, T.M.G., Koatale, P.C., Mahasha, P.W., Ndlovu, H., Vorster, M., Rodrigues, H.G., Zeevaart, J.R., Gordon, S., Moura-Alves, P. & Sathekge, M.M. (2021) COVID-19 Is a Multi-Organ Aggressor: Epigenetic and Clinical Marks. Frontiers in Immunology 12:752380. DOI: 10.3389/fimmu.2021.752380en_ZA
dc.identifier.issn1664-3224 (online)
dc.identifier.other10.3389/fimmu.2021.752380
dc.identifier.urihttp://hdl.handle.net/2263/84424
dc.language.isoenen_ZA
dc.publisherFrontiers Research Foundationen_ZA
dc.rights© 2021 Kgatle, Lawal,Mashabela, Boshomane, Koatale,Mahasha, Ndlovu, Vorster, Rodrigues, Zeevaart, Gordon, Moura-Alves and Sathekge. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY).en_ZA
dc.subjectCytokine stormen_ZA
dc.subjectEpigeneticsen_ZA
dc.subjectMulti-organen_ZA
dc.subjectPro-inflammatory cytokinesen_ZA
dc.subjectCoronavirus disease 2019 (COVID-19)en_ZA
dc.subjectCOVID-19 pandemicen_ZA
dc.subjectSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)en_ZA
dc.subjectAngiotensin-converting enzyme 2 (ACE2)en_ZA
dc.subjectTransmembrane serine protease 2 (TMPRSS2)en_ZA
dc.titleCOVID-19 Is a multi-organ aggressor : epigenetic and clinical marksen_ZA
dc.typeArticleen_ZA

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