COVID-19 Is a multi-organ aggressor : epigenetic and clinical marks
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Date
Authors
Kgatle, Mankgopo
Lawal, Ismaheel Opeyemi
Mashabela, Gabriel
Boshomane, Tebatso M.G.
Koatale, Palesa Caroline
Mahasha, Phetole Walter
Ndlovu, Honest
Vorster, Mariza
Rodrigues, Hosana Gomes
Zeevaart, Jan Rijn
Journal Title
Journal ISSN
Volume Title
Publisher
Frontiers Research Foundation
Abstract
The progression of coronavirus disease 2019 (COVID-19), resulting from a severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, may be influenced by both
genetic and environmental factors. Several viruses hijack the host genome machinery for
their own advantage and survival, and similar phenomena might occur upon SARS-CoV-2
infection. Severe cases of COVID-19 may be driven by metabolic and epigenetic driven
mechanisms, including DNA methylation and histone/chromatin alterations. These
epigenetic phenomena may respond to enhanced viral replication and mediate persistent
long-term infection and clinical phenotypes associated with severe COVID-19 cases and
fatalities. Understanding the epigenetic events involved, and their clinical significance, may
provide novel insights valuable for the therapeutic control and management of the COVID-
19 pandemic. This review highlights different epigenetic marks potentially associated with
COVID-19 development, clinical manifestation, and progression.
Description
Keywords
Cytokine storm, Epigenetics, Multi-organ, Pro-inflammatory cytokines, Coronavirus disease 2019 (COVID-19), COVID-19 pandemic, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Angiotensin-converting enzyme 2 (ACE2), Transmembrane serine protease 2 (TMPRSS2)
Sustainable Development Goals
Citation
Kgatle, M.M., Lawal, I.O., Mashabela, G., Boshomane, T.M.G., Koatale, P.C., Mahasha, P.W., Ndlovu, H., Vorster, M., Rodrigues, H.G., Zeevaart, J.R., Gordon, S., Moura-Alves, P. & Sathekge, M.M. (2021) COVID-19
Is a Multi-Organ Aggressor:
Epigenetic and Clinical Marks.
Frontiers in Immunology 12:752380.
DOI: 10.3389/fimmu.2021.752380