Dr Spur's mystery case : Is the answer in the gut?

Abstract

I have been treating a delightful young 16-year-old lady for a couple of years now in my practice. She has been diagnosed with selective IgA deficiency when she was six years old, after suffering from more than the usual amount of upper respiratory infections in comparison with her peers. She is also atopic suffering from allergic rhinitis and is sensitised to grasses. Unfortunately, she also developed type 1 Diabetes Mellitus when she was eight years old. Despite all her afflictions, she has a sunny disposition and is a very brave girl. I have come across articles where it is stated that IgA is particularly important in maintaining microbiome homeostasis. Can all her symptoms be contributed to a microbial dysbiosis? How can I manage her more optimally? Your opinion and guidance in this matter will be highly appreciated.