Prevalence of SLCO1B1 single nucleotide variations and their association with hypercholesterolaemia in hypercholesterolemic patients in Gauteng, South Africa

dc.contributor.authorDe Beer, Rene
dc.contributor.authorOuthoff, Kim
dc.contributor.authorPhulukdaree, Alisa
dc.contributor.authorSoma, Prashilla
dc.contributor.emailprashilla.soma@up.ac.zaen_ZA
dc.date.accessioned2022-02-09T05:04:53Z
dc.date.issued2021
dc.description.abstractStatins, the standard treatment for hypercholesterolaemia, among the most widely prescribed, have been associated with side effects, including statin intolerance. The aim of this study was to determine the background prevalence of SLCO1B1 SNVs in a randomly selected sample and to investigate if there are associations between SLCO1B1 SNVs and hypercholesterolaemia patients on statin therapy. Using Polymerase Chain Reaction - Restriction Fragment Length Polymorphism, the presence of SLCO1B1 SNVs (rs4149056, rs2306283 and rs4363657) was identified, while ELISA was used to quantify serum CK levels. Statin intolerance risk was calculated using a quantitative questionnaire. The risk of developing statin intolerance was found to be low (in 36%), moderate (in 49%), or high (in 15%) in the statin-treated group. The prevalence of the rs4149056 variant was 16% in (controls) and 20% in (statin) group; rs2306283 variant was present in 31.5% (controls), 10.5% in (statin) group; while the prevalence of the rs4363657 variant was similar in each. No association between the presence of any one of the SNVs and the statin intolerance severity risk score or CK elevation was found. These findings will facilitate a more personalized approach to statin therapy, especially relevant within the diverse South African population.en_ZA
dc.description.departmentAnatomyen_ZA
dc.description.departmentPharmacologyen_ZA
dc.description.departmentPhysiologyen_ZA
dc.description.embargo2022-06-30
dc.description.librarianhj2022en_ZA
dc.description.urihttp://www.tandfonline.com/loi/ixen20en_ZA
dc.identifier.citationDe Beer, R., Outhoff, K., Phulukdaree, A. & Soma, P. 2021, 'Prevalence of SLCO1B1 single nucleotide variations and their association with hypercholesterolaemia in hypercholesterolemic patients in Gauteng, South Africa', Xenobiotica, vol. 51, no. 8, pp. 949-959, DOI: 10.1080/00498254.2021.1945165.en_ZA
dc.identifier.issn0049-8254 (print)
dc.identifier.issn1366-5928 (online)
dc.identifier.other10.1080/00498254.2021.1945165
dc.identifier.urihttp://hdl.handle.net/2263/83683
dc.language.isoenen_ZA
dc.publisherTaylor and Francisen_ZA
dc.rights© 2021 Informa UK Limited, trading as Taylor & Francis Group. This is an electronic version of an article published in Xenobiotica, vol. 51, no. 8, pp. 949-959, 2021. doi : 10.1080/00498254.2021.1945165. Xenobiotica is available online at: http://www.tandfonline.com/loi/ixen20.en_ZA
dc.subjectSolute carrier organic anion transporter family member 1B1 (SLCO1B1)en_ZA
dc.subjectStatinsen_ZA
dc.subjectStatin intoleranceen_ZA
dc.subjectHypercholesterolaemiaen_ZA
dc.subjectAtorvastatinen_ZA
dc.subjectSimvastatinen_ZA
dc.subjectSingle nucleotide variation (SNV)en_ZA
dc.subjectCreatine kinaseen_ZA
dc.subjectEnzyme-linked immunosorbent assay (ELISA)en_ZA
dc.subject.otherHealth sciences articles SDG-03
dc.subject.otherSDG-03: Good health and well-being
dc.titlePrevalence of SLCO1B1 single nucleotide variations and their association with hypercholesterolaemia in hypercholesterolemic patients in Gauteng, South Africaen_ZA
dc.typePostprint Articleen_ZA

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