Sorghum condensed tannins encapsulated in kafirin microparticles as a nutraceutical for inhibition of amylases during digestion to attenuate hyperglycaemia

dc.contributor.authorLinks, Malory R.
dc.contributor.authorTaylor, Janet
dc.contributor.authorKruger, Marlena C.
dc.contributor.authorTaylor, J.R.N. (John Reginald Nuttall)
dc.contributor.emailjohn.taylor@up.ac.zaen_ZA
dc.date.accessioned2015-01-30T05:42:27Z
dc.date.available2015-01-30T05:42:27Z
dc.date.issued2015-01
dc.description.abstractType 2 diabetes (T2D) is increasing rapidly in Africa. An appropriate therapeutic approach is to inhibit intestinal carbohydrate digesting enzymes using plant polyphenols. A crude preparation of sorghum condensed tannins (SCT) was highly effective (approx. 20,000 times) at inhibiting α-glucosidase compared to acarbose, while acarbose was a better α-amylase inhihitor (approx. 180 times). Kafirin microparticles (KEMS) were investigated as an oral delivery system for SCT. Using a simple aqueous alcohol coacervation method, the encapulation efficiency of SCT in the KEMS was approx. 48%. Quantitative data and electron microscopy revealed that KEMS encapsulating SCT were digested to only a limited extent during simulated gastrointestinal digestion with pepsin and trypsin–chymotrypsin. Hence, SCT encapsulated in KEMS retained their inhibitory activity against both amylases, throughout simulated gastrointestinal digestion, whereas unencapsulated SCT lost most of their inhibitory activity.Thus, KEMS encapsulating SCT have potential as a nutraceutical to attenuate hyperglycaemia and control T2D.en_ZA
dc.description.librarianhb2015en_ZA
dc.description.sponsorshipSouth African National Research Foundation (84886), University of Pretoria and the Technology for Human Resources for Industry Programme of South Africa.en_ZA
dc.description.urihttp://www.elsevier.com/locate/jffen_ZA
dc.identifier.citationLinks, MR, Taylor, J, Kruger, MC & Taylor, JRN 2015, 'Sorghum condensed tannins encapsulated in kafirin microparticles as a nutraceutical for inhibition of amylases during digestion to attenuate hyperglycaemia', Journal of Functional Foods, vol. 12, pp. 55-63.en_ZA
dc.identifier.issn1756-4646 (print)
dc.identifier.other10.1016/j.jff.2014.11.003
dc.identifier.urihttp://hdl.handle.net/2263/43491
dc.language.isoenen_ZA
dc.publisherElsevieren_ZA
dc.rights© 2014 Elsevier Ltd. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Journal of Functional Foods. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Functional Foods, vol. 12, pp. 55-63, 2015. doi : 10.1016/j.jff.2014.11.003.en_ZA
dc.subjectAmylase inhibitionen_ZA
dc.subjectKafirinen_ZA
dc.subjectMicroparticlesen_ZA
dc.subjectSorghum condensed tanninsen_ZA
dc.subjectKafirin microparticles (KEMS)en_ZA
dc.subjectType 2 diabetes mellitus (T2DM)en_ZA
dc.subject.otherHealth sciences articles SDG-02
dc.subject.otherSDG-02: Zero hunger
dc.subject.otherHealth sciences articles SDG-03
dc.subject.otherSDG-03: Good health and well-being
dc.subject.otherHealth sciences articles SDG-09
dc.subject.otherSDG-09: Industry, innovation and infrastructure
dc.subject.otherHealth sciences articles SDG-12
dc.subject.otherSDG-12: Responsible consumption and production
dc.titleSorghum condensed tannins encapsulated in kafirin microparticles as a nutraceutical for inhibition of amylases during digestion to attenuate hyperglycaemiaen_ZA
dc.typePostprint Articleen_ZA

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