Sorghum condensed tannins encapsulated in kafirin microparticles as a nutraceutical for inhibition of amylases during digestion to attenuate hyperglycaemia
| dc.contributor.author | Links, Malory R. | |
| dc.contributor.author | Taylor, Janet | |
| dc.contributor.author | Kruger, Marlena C. | |
| dc.contributor.author | Taylor, J.R.N. (John Reginald Nuttall) | |
| dc.contributor.email | john.taylor@up.ac.za | en_ZA |
| dc.date.accessioned | 2015-01-30T05:42:27Z | |
| dc.date.available | 2015-01-30T05:42:27Z | |
| dc.date.issued | 2015-01 | |
| dc.description.abstract | Type 2 diabetes (T2D) is increasing rapidly in Africa. An appropriate therapeutic approach is to inhibit intestinal carbohydrate digesting enzymes using plant polyphenols. A crude preparation of sorghum condensed tannins (SCT) was highly effective (approx. 20,000 times) at inhibiting α-glucosidase compared to acarbose, while acarbose was a better α-amylase inhihitor (approx. 180 times). Kafirin microparticles (KEMS) were investigated as an oral delivery system for SCT. Using a simple aqueous alcohol coacervation method, the encapulation efficiency of SCT in the KEMS was approx. 48%. Quantitative data and electron microscopy revealed that KEMS encapsulating SCT were digested to only a limited extent during simulated gastrointestinal digestion with pepsin and trypsin–chymotrypsin. Hence, SCT encapsulated in KEMS retained their inhibitory activity against both amylases, throughout simulated gastrointestinal digestion, whereas unencapsulated SCT lost most of their inhibitory activity.Thus, KEMS encapsulating SCT have potential as a nutraceutical to attenuate hyperglycaemia and control T2D. | en_ZA |
| dc.description.librarian | hb2015 | en_ZA |
| dc.description.sponsorship | South African National Research Foundation (84886), University of Pretoria and the Technology for Human Resources for Industry Programme of South Africa. | en_ZA |
| dc.description.uri | http://www.elsevier.com/locate/jff | en_ZA |
| dc.identifier.citation | Links, MR, Taylor, J, Kruger, MC & Taylor, JRN 2015, 'Sorghum condensed tannins encapsulated in kafirin microparticles as a nutraceutical for inhibition of amylases during digestion to attenuate hyperglycaemia', Journal of Functional Foods, vol. 12, pp. 55-63. | en_ZA |
| dc.identifier.issn | 1756-4646 (print) | |
| dc.identifier.other | 10.1016/j.jff.2014.11.003 | |
| dc.identifier.uri | http://hdl.handle.net/2263/43491 | |
| dc.language.iso | en | en_ZA |
| dc.publisher | Elsevier | en_ZA |
| dc.rights | © 2014 Elsevier Ltd. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Journal of Functional Foods. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Functional Foods, vol. 12, pp. 55-63, 2015. doi : 10.1016/j.jff.2014.11.003. | en_ZA |
| dc.subject | Amylase inhibition | en_ZA |
| dc.subject | Kafirin | en_ZA |
| dc.subject | Microparticles | en_ZA |
| dc.subject | Sorghum condensed tannins | en_ZA |
| dc.subject | Kafirin microparticles (KEMS) | en_ZA |
| dc.subject | Type 2 diabetes mellitus (T2DM) | en_ZA |
| dc.subject.other | Health sciences articles SDG-02 | |
| dc.subject.other | SDG-02: Zero hunger | |
| dc.subject.other | Health sciences articles SDG-03 | |
| dc.subject.other | SDG-03: Good health and well-being | |
| dc.subject.other | Health sciences articles SDG-09 | |
| dc.subject.other | SDG-09: Industry, innovation and infrastructure | |
| dc.subject.other | Health sciences articles SDG-12 | |
| dc.subject.other | SDG-12: Responsible consumption and production | |
| dc.title | Sorghum condensed tannins encapsulated in kafirin microparticles as a nutraceutical for inhibition of amylases during digestion to attenuate hyperglycaemia | en_ZA |
| dc.type | Postprint Article | en_ZA |