Sorghum condensed tannins encapsulated in kafirin microparticles as a nutraceutical for inhibition of amylases during digestion to attenuate hyperglycaemia
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Date
Authors
Links, Malory R.
Taylor, Janet
Kruger, Marlena C.
Taylor, J.R.N. (John Reginald Nuttall)
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Type 2 diabetes (T2D) is increasing rapidly in Africa. An appropriate therapeutic approach
is to inhibit intestinal carbohydrate digesting enzymes using plant polyphenols. A crude
preparation of sorghum condensed tannins (SCT) was highly effective (approx. 20,000 times)
at inhibiting α-glucosidase compared to acarbose, while acarbose was a better α-amylase
inhihitor (approx. 180 times). Kafirin microparticles (KEMS) were investigated as an oral delivery
system for SCT. Using a simple aqueous alcohol coacervation method, the encapulation
efficiency of SCT in the KEMS was approx. 48%. Quantitative data and electron microscopy
revealed that KEMS encapsulating SCT were digested to only a limited extent during simulated
gastrointestinal digestion with pepsin and trypsin–chymotrypsin. Hence, SCT
encapsulated in KEMS retained their inhibitory activity against both amylases, throughout
simulated gastrointestinal digestion, whereas unencapsulated SCT lost most of their inhibitory
activity.Thus, KEMS encapsulating SCT have potential as a nutraceutical to attenuate
hyperglycaemia and control T2D.
Description
Keywords
Amylase inhibition, Kafirin, Microparticles, Sorghum condensed tannins, Kafirin microparticles (KEMS), Type 2 diabetes mellitus (T2DM)
Sustainable Development Goals
Citation
Links, MR, Taylor, J, Kruger, MC & Taylor, JRN 2015, 'Sorghum condensed tannins encapsulated in kafirin microparticles as a nutraceutical for inhibition of amylases during digestion to attenuate hyperglycaemia', Journal of Functional Foods, vol. 12, pp. 55-63.