Primary ciliary dyskinesia : meeting the challenges of diagnosis in South Africa

dc.contributor.authorDangor, Z.
dc.contributor.authorBirkhead, M.
dc.contributor.authorVerwey, C.
dc.contributor.authorGray, D.M.
dc.contributor.authorVanker, A.
dc.contributor.authorGithingi, L.
dc.contributor.authorGoga, Ameena Ebrahim
dc.contributor.authorMasekela, R.
dc.contributor.authorZampoli, M.
dc.date.accessioned2025-07-02T04:49:53Z
dc.date.available2025-07-02T04:49:53Z
dc.date.issued2024-08
dc.description.abstractPrimary ciliary dyskinesia (PCD) is an inherited ciliopathy that results in impaired mucous clearance and affects primarily the respiratory tract, causing upper airway disease, bronchial inflammation and bronchiectasis. The prevalence of PCD in low- and middle-income settings, including South Africa (SA), is unknown, largely owing to challenges with diagnosis, and identifying children or adults with PCD is challenging in a setting with a high prevalence of other infectious diseases, including lower respiratory tract infections and tuberculosis. No single test is diagnostic of PCD, and while some tests are costly, others are labour intensive and require highly specialised laboratory expertise. In the SA setting, awareness and opportunities for the diagnosis of PCD need to be created. In this commentary, we provide a pragmatic approach to identifying which children and adults require further investigations for PCD using a range of diagnostic tests or tools that are available. Furthermore, we recommend that designated centres of expertise for PCD diagnosis are created in SA. This would be an important step towards improving accessibility of diagnostic tests and developing local expertise to improving PCD diagnosis, especially in early childhood, to prevent long-term irreversible respiratory sequelae.
dc.description.departmentPaediatrics and Child Health
dc.description.librarianam2025
dc.description.sdgSDG-03: Good health and well-being
dc.description.urihttp://www.samj.org.za/index.php/samj
dc.identifier.citationDangor, Z., Birkhead, M., Verwey, C. et al. 2024, 'Primary ciliary dyskinesia : meeting the challenges of diagnosis in South Africa', South African Medical Journal, vol. 114, no. 8, pp. 16-19. https://doi.org/10.7196/SAMJ.2024.v114i8.2069.
dc.identifier.issn0256-9574 (print)
dc.identifier.issn2078-5135 (online)
dc.identifier.other10.7196/SAMJ.2024.v114i8.2069
dc.identifier.urihttp://hdl.handle.net/2263/103086
dc.language.isoen
dc.publisherSouth African Medical Association
dc.rights© 2024 Z Dangor, M Birkhead, C Verwey, D Gray, A Vanker, L Githinji, A Goga, R Masekela, M Zampoli. This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
dc.subjectInherited ciliopathy
dc.subjectPrimary ciliary dyskinesia (PCD)
dc.subjectDiagnosis
dc.subjectLow- and middle-income countries (LMICs)
dc.subjectSouth Africa (SA)
dc.subjectDiagnosis
dc.subjectUpper airway disease
dc.subjectBronchial inflammation
dc.subjectBronchiectasis
dc.titlePrimary ciliary dyskinesia : meeting the challenges of diagnosis in South Africa
dc.typeArticle

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Dangor_Primary_2024.pdf
Size:
873.58 KB
Format:
Adobe Portable Document Format
Description:
Article

License bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: