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dc.contributor.author | Moyo, Phanankosi![]() |
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dc.contributor.author | Invernizzi, Luke![]() |
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dc.contributor.author | Mianda, Sephora Mutombo![]() |
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dc.contributor.author | Andayi, Warren A.![]() |
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dc.contributor.author | Wang, Mingxun![]() |
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dc.contributor.author | Crouch, Neil R.![]() |
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dc.contributor.author | Maharaj, Vinesh J.![]() |
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dc.date.accessioned | 2024-08-30T11:02:06Z | |
dc.date.available | 2024-08-30T11:02:06Z | |
dc.date.issued | 2023-10-05 | |
dc.description | AVAILABILITY OF DATA AND MATERIAL : The data that support the findings of this study are available from the corresponding author upon reasonable request. | en_US |
dc.description.abstract | The antimalarial drug-resistance conundrum which threatens to reverse the great strides taken to curb the malaria scourge warrants an urgent need to find novel chemical scaffolds to serve as templates for the development of new antimalarial drugs. Plants represent a viable alternative source for the discovery of unique potential antiplasmodial chemical scaffolds. To expedite the discovery of new antiplasmodial compounds from plants, the aim of this study was to use phylogenetic analysis to identify higher plant orders and families that can be rationally prioritised for antimalarial drug discovery. We queried the PubMed database for publications documenting antiplasmodial properties of natural compounds isolated from higher plants. Thereafter, we manually collated compounds reported along with plant species of origin and relevant pharmacological data. We systematically assigned antiplasmodial-associated plant species into recognised families and orders, and then computed the resistance index, selectivity index and physicochemical properties of the compounds from each taxonomic group. Correlating the generated phylogenetic trees and the biological data of each clade allowed for the identification of 3 ‘hot’ plant orders and families. The top 3 ranked plant orders were the (i) Caryophyllales, (ii) Buxales, and (iii) Chloranthales. The top 3 ranked plant families were the (i) Ancistrocladaceae, (ii) Simaroubaceae, and (iii) Buxaceae. The highly active natural compounds ( IC50 ≤ 1 μM) isolated from these plant orders and families are structurally unique to the ‘legacy’ antimalarial drugs. Our study was able to identify the most prolific taxa at order and family rank that we propose be prioritised in the search for potent, safe and drug-like antimalarial molecules. | en_US |
dc.description.department | Chemistry | en_US |
dc.description.librarian | am2024 | en_US |
dc.description.sdg | SDG-03:Good heatlh and well-being | en_US |
dc.description.sdg | SDG-15:Life on land | en_US |
dc.description.sponsorship | The Department of Science and Innovation (DSI) of South Africa, the University of Pretoria, the L’Oréal-UNESCO for Woman in Science and National Research Foundation of South Africa. | en_US |
dc.description.uri | https://link.springer.com/journal/13659 | en_US |
dc.identifier.citation | Moyo, P., Invernizzi, L., Mianda, S.M. et al. 2023, 'Leveraging off higher plant phylogenetic insights for antiplasmodial drug discovery', Natural Products and Bioprospecting, vol. 13, no. 35, pp. 1-18. https://DOI.org/10.1007/s13659-023-00396-x. | en_US |
dc.identifier.issn | 2192-2209 (online) | |
dc.identifier.other | 10.1007/s13659-023-00396-x | |
dc.identifier.uri | http://hdl.handle.net/2263/97944 | |
dc.language.iso | en | en_US |
dc.publisher | Springer | en_US |
dc.rights | © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License. | en_US |
dc.subject | Natural products | en_US |
dc.subject | Plants | en_US |
dc.subject | Phylogenetics | en_US |
dc.subject | Malaria | en_US |
dc.subject | Drug-resistance | en_US |
dc.subject | ‘Hot’ plants | en_US |
dc.subject | SDG-03: Good health and well-being | en_US |
dc.subject | SDG-15: Life on land | en_US |
dc.title | Leveraging off higher plant phylogenetic insights for antiplasmodial drug discovery | en_US |
dc.type | Article | en_US |