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dc.contributor.author | Von Gottberg, Anne![]() |
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dc.contributor.author | Kleynhans, Jackie![]() |
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dc.contributor.author | De Gouveia, Linda![]() |
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dc.contributor.author | Tempia, Stefano![]() |
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dc.contributor.author | Meiring, Susan![]() |
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dc.contributor.author | Quan, Vanessa![]() |
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dc.contributor.author | Du Plessis, Mignon![]() |
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dc.contributor.author | Von Mollendorf, Claire![]() |
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dc.contributor.author | Crowther-Gibson, Penny![]() |
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dc.contributor.author | Avenant, Theunis Johannes![]() |
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dc.contributor.author | Du Plessis, Nicolette Marie![]() |
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dc.contributor.author | Kularatne, Ranmini![]() |
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dc.contributor.author | Chibabhai, Vindana![]() |
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dc.contributor.author | Madhi, Shabir A.![]() |
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dc.contributor.author | Klugman, Keith P.![]() |
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dc.contributor.author | Whitney, Cynthia G.![]() |
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dc.contributor.author | Cohen, Cheryl![]() |
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dc.date.accessioned | 2024-08-26T06:24:24Z | |
dc.date.available | 2024-08-26T06:24:24Z | |
dc.date.issued | 2024-09 | |
dc.description | DATA SHARING : We welcome enquiries about possible collaborations and requests for access to the dataset. Data (including individual participant data and a data dictionary defining each field in the set) will be shared after the approval of a proposal and with a signed data access agreement. Investigators interested in more details about this study, or in accessing these resources, should contact the principle investigator and corresponding author ( annev@nicd.ac.za ). | |
dc.description.abstract | BACKGROUND : In South Africa, 7-valent pneumococcal conjugate vaccine (PCV7) was introduced in 2009 and 13-valent PCV (PCV13) was introduced in 2011, both in a two plus one schedule. We evaluated the ongoing effects of PCV on the prevention of invasive pneumococcal disease (IPD) over 15 years of sustained surveillance in South Africa before the COVID-19 pandemic. METHODS : We conducted national, active, laboratory-based surveillance for IPD among all ages in South Africa, including isolate serotyping and susceptibility testing. We fitted linear regression models with vaccine covariates to imputed IPD case counts each year by serotype and age to compare expected and actual IPD cases in 2019, which was the main outcome. Vaccine effects were set to zero to identify expected incidence after the introduction of PCV7 and PCV13. FINDINGS : From Jan 1, 2005, to Dec 31, 2019, surveillance identified 52 957 IPD cases. Among the 50 705 individuals with age data available, 9398 (18·5%) were infants aged younger than 2 years. Compared with expected case numbers (no vaccination) predicted using all available data, overall IPD rates among children younger than 2 years declined by 76·0% (percentage risk difference; 95% CI –79·0 to –72·8%) in 2019; notably, PCV7 and additional PCV13 serotype IPD rates declined by 95·5% (–97·0 to –93·4%) and 93·8% (–96·2 to–90·5%), respectively, whereas non-vaccine serotypes (NVTs) did not change significantly. Among adults aged 25–44 years, overall IPD declined by 50·4% (–54·2 to –46·3%), and PCV7 and additional PCV13 serotype IPD rates declined by 86·1% (–88·7 to –83·1%) and 77·2% (–80·9 to –73·0%), respectively, whereas NVTs increased by 78·5% (56·8 to 103·4%). Individuals aged older than 64 years also benefited from declines in IPD (–30·2%; –41·9 to –16·2%), but NVTs increased (234·9%; 138·1 to 379·4%). INTERPRETATION : We documented sustained direct and indirect benefits of PCV across age groups, and NVT increases in adults older than 24 years. Higher valency PCVs would have the added benefit of preventing this residual disease. | en_US |
dc.description.department | Paediatrics and Child Health | en_US |
dc.description.librarian | hj2024 | en_US |
dc.description.sdg | SDG-03:Good heatlh and well-being | en_US |
dc.description.sponsorship | National Institute for Communicable Diseases of the National Health Laboratory Service (South Africa) and US Agency for International Development Antimicrobial Resistance Initiative, US Centers for Disease Control and Prevention. | en_US |
dc.description.uri | http://www.thelancet.com/lancetgh | en_US |
dc.identifier.citation | Von Gottberg, A., Kleynhans, J., De Gouveia, L. et al. 2024, 'Long-term effect of pneumococcal conjugate vaccines on invasive pneumococcal disease incidence among people of all ages from national, active, laboratory-based surveillance in South Africa, 2005–19 : a cohort observational study', Lancet Global Health, vol. 12, no. 9, pp. e1470-e1484, doi : 10.1016/S2214-109X(24)00263-8. | en_US |
dc.identifier.issn | 2214-109X (online) | |
dc.identifier.other | 10.1016/S2214-109X(24)00263-8 | |
dc.identifier.uri | http://hdl.handle.net/2263/97847 | |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | © 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC 4.0 license. | en_US |
dc.subject | 7-Valent pneumococcal conjugate vaccine (PCV7) | en_US |
dc.subject | 13-Valent pneumococcal conjugate vaccine (PCV13) | en_US |
dc.subject | Invasive pneumococcal disease (IPD) | en_US |
dc.subject | South Africa (SA) | en_US |
dc.subject | Pneumococcal conjugate vaccine (PCV) | en_US |
dc.subject | Non-vaccine serotype (NVT) | en_US |
dc.subject | SDG-03: Good health and well-being | en_US |
dc.title | Long-term effect of pneumococcal conjugate vaccines on invasive pneumococcal disease incidence among people of all ages from national, active, laboratory-based surveillance in South Africa, 2005–19 : a cohort observational study | en_US |
dc.type | Article | en_US |