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dc.contributor.author | Roug, Annette![]() |
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dc.contributor.author | Smith, C.![]() |
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dc.contributor.author | Raath, J.P.![]() |
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dc.contributor.author | Meyer, Leith Carl Rodney![]() |
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dc.contributor.author | Laubscher, L.L.![]() |
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dc.date.accessioned | 2024-08-15T10:19:34Z | |
dc.date.available | 2024-08-15T10:19:34Z | |
dc.date.issued | 2023-02 | |
dc.description.abstract | African wildlife species are increasingly being immobilised with combinations of a low dose of potent opioids combined with medetomidine and azaperone. The physiological effects of these combinations in comparison to conventional potent opioidazaperone combinations have scarcely been evaluated. In this cross-over study conducted on eight captive blesbok, we compared the physiological variables of blesbok immobilised with 2 mg of thiafentanil + 10 mg of azaperone (TA); 0.5 mg thiafentanil + 1.5 mg medetomidine (TM), and 0.5 mg thiafentanil + 1.5. mg medetomidine + 10 mg azaperone (TMA). Thiafentanil’s effects were antagonised with naltrexone at 10 mg naltrexone per mg thiafentanil, and the medetomidine effects with atipamezole at 5 mg atipamezole per mg medetomidine. The physiological variables were compared between treatment groups using descriptive statistics and repeated measures ANOVA. The TA combination resulted in the shortest induction and recovery times, higher heart rates, respiratory rates, PaO2, SpO2, and lower MAP and A-a gradients, but with less muscle relaxation. The TM and TMA combinations caused marked bradycardia and hypoxaemia. The hypoxaemia was most severe in animals immobilised with TMA, and four of eight blesbok immobilised had a PaO2 < 35 mmHg at the 10- or 15-minute sampling point. These blesbok were provided supplementary oxygen, which corrected the hypoxaemia. The TA combinations caused the lowest degree of physiological compromise. All three combinations were effective for the immobilisation of blesbok, but as the low-dose thiafentanil and high-dose medetomidine combinations caused marked hypoxaemia, supplementary oxygen is recommended when using these combinations. | en_US |
dc.description.department | Centre for Veterinary Wildlife Studies | en_US |
dc.description.department | Paraclinical Sciences | en_US |
dc.description.department | Production Animal Studies | en_US |
dc.description.librarian | am2024 | en_US |
dc.description.sdg | SDG-03:Good heatlh and well-being | en_US |
dc.description.sdg | SDG-15:Life on land | en_US |
dc.description.sponsorship | An American Association of Zoo Veterinarians (AAZV) Wild Animal Health Fund grant and the facility and equipment provided by Wildlife Pharmaceuticals South Africa (Pty) Ltd, and the University of Pretoria. | en_US |
dc.description.uri | http://www.jsava.co.za | en_US |
dc.identifier.citation | Roug, A., Smith, C., Raath, J.P. 2023, 'Efficacy and safety of three different opioid-based immobilisation combinations in blesbok (Damaliscus pygargus phillipsi)', Journal of the South African Veterinary Association, vol. 94, no. 1, pp. 145-152. https://DOI.org/10.36303/JSAVA.567. | en_US |
dc.identifier.issn | 2224-9435 (print) | |
dc.identifier.issn | 1019-9128 (online) | |
dc.identifier.other | 10.36303/JSAVA.567 | |
dc.identifier.uri | http://hdl.handle.net/2263/97659 | |
dc.language.iso | en | en_US |
dc.publisher | MedPharm Publications | en_US |
dc.rights | © 2023 The Author(s). Open Access article distributed under the terms of the Creative Commons License [CC BY-NC 3.0] | en_US |
dc.subject | Thiafentanil | en_US |
dc.subject | Medetomidine | en_US |
dc.subject | Azaperone | en_US |
dc.subject | Chemical immobilisation | en_US |
dc.subject | Hypoxaemia | en_US |
dc.subject | Blesbok (Damaliscus pygargus phillipsi) | en_US |
dc.subject | SDG-03: Good health and well-being | en_US |
dc.subject | SDG-15: Life on land | en_US |
dc.title | Efficacy and safety of three different opioid-based immobilisation combinations in blesbok (Damaliscus pygargus phillipsi) | en_US |
dc.type | Article | en_US |