Efficacy and safety of three different opioid-based immobilisation combinations in blesbok (Damaliscus pygargus phillipsi)

dc.contributor.authorRoug, Annette
dc.contributor.authorSmith, C.
dc.contributor.authorRaath, J.P.
dc.contributor.authorMeyer, Leith Carl Rodney
dc.contributor.authorLaubscher, L.L.
dc.date.accessioned2024-08-15T10:19:34Z
dc.date.available2024-08-15T10:19:34Z
dc.date.issued2023-02
dc.description.abstractAfrican wildlife species are increasingly being immobilised with combinations of a low dose of potent opioids combined with medetomidine and azaperone. The physiological effects of these combinations in comparison to conventional potent opioidazaperone combinations have scarcely been evaluated. In this cross-over study conducted on eight captive blesbok, we compared the physiological variables of blesbok immobilised with 2 mg of thiafentanil + 10 mg of azaperone (TA); 0.5 mg thiafentanil + 1.5 mg medetomidine (TM), and 0.5 mg thiafentanil + 1.5. mg medetomidine + 10 mg azaperone (TMA). Thiafentanil’s effects were antagonised with naltrexone at 10 mg naltrexone per mg thiafentanil, and the medetomidine effects with atipamezole at 5 mg atipamezole per mg medetomidine. The physiological variables were compared between treatment groups using descriptive statistics and repeated measures ANOVA. The TA combination resulted in the shortest induction and recovery times, higher heart rates, respiratory rates, PaO2, SpO2, and lower MAP and A-a gradients, but with less muscle relaxation. The TM and TMA combinations caused marked bradycardia and hypoxaemia. The hypoxaemia was most severe in animals immobilised with TMA, and four of eight blesbok immobilised had a PaO2 < 35 mmHg at the 10- or 15-minute sampling point. These blesbok were provided supplementary oxygen, which corrected the hypoxaemia. The TA combinations caused the lowest degree of physiological compromise. All three combinations were effective for the immobilisation of blesbok, but as the low-dose thiafentanil and high-dose medetomidine combinations caused marked hypoxaemia, supplementary oxygen is recommended when using these combinations.en_US
dc.description.departmentCentre for Veterinary Wildlife Studiesen_US
dc.description.departmentParaclinical Sciencesen_US
dc.description.departmentProduction Animal Studiesen_US
dc.description.librarianam2024en_US
dc.description.sdgSDG-03:Good heatlh and well-beingen_US
dc.description.sdgSDG-15:Life on landen_US
dc.description.sponsorshipAn American Association of Zoo Veterinarians (AAZV) Wild Animal Health Fund grant and the facility and equipment provided by Wildlife Pharmaceuticals South Africa (Pty) Ltd, and the University of Pretoria.en_US
dc.description.urihttp://www.jsava.co.zaen_US
dc.identifier.citationRoug, A., Smith, C., Raath, J.P. 2023, 'Efficacy and safety of three different opioid-based immobilisation combinations in blesbok (Damaliscus pygargus phillipsi)', Journal of the South African Veterinary Association, vol. 94, no. 1, pp. 145-152. https://DOI.org/10.36303/JSAVA.567.en_US
dc.identifier.issn2224-9435 (print)
dc.identifier.issn1019-9128 (online)
dc.identifier.other10.36303/JSAVA.567
dc.identifier.urihttp://hdl.handle.net/2263/97659
dc.language.isoenen_US
dc.publisherMedPharm Publicationsen_US
dc.rights© 2023 The Author(s). Open Access article distributed under the terms of the Creative Commons License [CC BY-NC 3.0]en_US
dc.subjectThiafentanilen_US
dc.subjectMedetomidineen_US
dc.subjectAzaperoneen_US
dc.subjectChemical immobilisationen_US
dc.subjectHypoxaemiaen_US
dc.subjectBlesbok (Damaliscus pygargus phillipsi)en_US
dc.subjectSDG-03: Good health and well-beingen_US
dc.subjectSDG-15: Life on landen_US
dc.titleEfficacy and safety of three different opioid-based immobilisation combinations in blesbok (Damaliscus pygargus phillipsi)en_US
dc.typeArticleen_US

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