Please be advised that the site will be down for maintenance on Sunday, September 1, 2024, from 08:00 to 18:00, and again on Monday, September 2, 2024, from 08:00 to 09:00. We apologize for any inconvenience this may cause.
dc.contributor.author | Mitchell, Emily P.![]() |
|
dc.contributor.author | Henker, Melanie S.![]() |
|
dc.contributor.author | Lemberger, Karin![]() |
|
dc.contributor.author | Gohl, Christine![]() |
|
dc.contributor.author | Majzoub-Altweck, Monir![]() |
|
dc.contributor.author | Falkenau, Almuth![]() |
|
dc.contributor.author | Caldwell, Peter![]() |
|
dc.contributor.author | Chenet, Baptiste![]() |
|
dc.contributor.author | Mosca, Marion![]() |
|
dc.contributor.author | Pin, Didier![]() |
|
dc.contributor.author | Denk, Daniela![]() |
|
dc.date.accessioned | 2024-08-07T11:52:04Z | |
dc.date.available | 2024-08-07T11:52:04Z | |
dc.date.issued | 2023-11 | |
dc.description | AVAILABILITY OF DATA AND MATERIAL : Part of the case material included in the present study that derived from France was included in a poster presentation on familial occurrence of CATs in AWDs (cases 2, 9, 10 and 11) [19]. These cases and cases 3 and 8 were also included in a poster presentation as part of a retrospective study on neoplasms in AWDs in French zoological collections [7]. | en_US |
dc.description.abstract | This retrospective study documents the occurrence of single and multiple cutaneous apocrine gland tumours (CATs) on the dorsal midline of 16 captive African wild dogs (AWDs, Lycaon pictus) derived from 161 submissions to diagnostic laboratories in South Africa, France and Germany between 1997 and 2022. Animals included in the study came from zoological institutions in South Africa (n ¼ 2), France (n ¼ 5) and Germany (n ¼ 1) and ranged from 5 to 14 years of age. Fifteen affected animals were female (94%) and one was male. CATs presented as raised, hairless, multilobular, grey firm masses, consistently located along the dorsal midline. Apart from a single cutaneous apocrine adenoma and a cystadenoma occurring concurrently with two non-cystic adenocarcinomas, neoplasms were consistent with malignant cutaneous apocrine adenocarcinomas with lymphatic spread and visceral metastases. Advanced age and female sex were identified as risk factors. A genetic component or association with the increasing use of GnRH agonist contraceptives was suspected but could not be established. This study highlights the need for close clinical monitoring of AWDs over the age of 5 years for the development of CATs along the dorsal midline and supports early surgical intervention. More research is needed to determine the role of inbreeding, endocrine changes and husbandry factors that may play a role in the development of CATs on the dorsal midline of AWDs. | en_US |
dc.description.department | Centre for Veterinary Wildlife Studies | en_US |
dc.description.department | Paraclinical Sciences | en_US |
dc.description.librarian | am2024 | en_US |
dc.description.sdg | SDG-03:Good heatlh and well-being | en_US |
dc.description.uri | http://www.elsevier.com/locate/jcpa | en_US |
dc.identifier.citation | Mitchell, E.P., Henker, M.S., Lemberger, K. et al. 2023, 'Cutaneous apocrine gland neoplasia in 16 captive African wild dogs (Lycaon pictus)', Journal of Comparative Pathology, vol. 207, pp. 59-65. https://DOI.org/10.1016/j.jcpa.2023.10.005. | en_US |
dc.identifier.issn | 0021-9975 (print) | |
dc.identifier.issn | 1532-3129 (online) | |
dc.identifier.other | 10.1016/j.jcpa.2023.10.005 | |
dc.identifier.uri | http://hdl.handle.net/2263/97495 | |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | © 2023 The Authors. This is an open access article under the CC BY-NC-ND license. | en_US |
dc.subject | Dorsal midline | en_US |
dc.subject | Lycaon pictus | en_US |
dc.subject | Metastasis | en_US |
dc.subject | Neoplasia | en_US |
dc.subject | Skin | en_US |
dc.subject | African wild dog (Lycaon pictus) | en_US |
dc.subject | Cutaneous apocrine gland tumours (CATs) | en_US |
dc.subject | Cutaneous apocrine adenocarcinoma | en_US |
dc.subject | Adenoma | en_US |
dc.subject | Cystadenoma | en_US |
dc.subject | SDG-03: Good health and well-being | en_US |
dc.title | Cutaneous apocrine gland neoplasia in 16 captive African wild dogs (Lycaon pictus) | en_US |
dc.type | Article | en_US |