Structure and function of murine cytomegalovirus MHC-I-like molecules : how the virus turned the host defense to its advantage

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dc.contributor.author Mans, Janet
dc.contributor.author Zhi, Li
dc.contributor.author Revilleza, Maria Jamela R.
dc.contributor.author Smith, Lee
dc.contributor.author Redwood, Alec
dc.contributor.author Natarajan, Kannan
dc.contributor.author Margulies, David H.
dc.date.accessioned 2009-04-03T11:51:35Z
dc.date.available 2009-04-03T11:51:35Z
dc.date.issued 2009
dc.description.abstract The mouse cytomegalovirus (CMV), a β-herpesvirus, exploits its large (~230 kb) double-stranded DNA genome for both essential and non-essential functions. Among the non-essential functions are those that offer the virus a selective advantage in eluding both the innate and adaptive immune responses of the host. Several non-essential genes of MCMV are thought to encode MHC-I-like genes and to function as immunoevasins. To understand further the evolution and function of these viral MHC-I (MHC-Iv) molecules, X-ray structures of several of them have been determined, not only confirming the overall MHC-I-like structure, but also elucidating features unique to this family. Future efforts promise to clarify the nature of the molecular ligands of these molecules, their evolution in the context of the adapting immune response of the murine host, and by analogy the evolution of the host response to human CMV as well. This review is based in part on a Doctoral Dissertation submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa, for the degree of Doctor of Philosophy by Janet Mans [1]. en_US
dc.identifier.citation Mans, J, Zhi, L, Revilleza, MJR, Smith, L, Redwood, A, Natarajan, K & Margulies, DH 2009, ‘Structure and function of murine cytomegalovirus MHC-I-like molecules : how the virus turned the host defense to its advantage’, Immunologic Research, vol. 43, no. 1-3, pp. 264-279. [http://www.springerlink.com/content/120562/] en_US
dc.identifier.issn 0257-277X
dc.identifier.other 10.1007/s12026-008-8081-6
dc.identifier.uri http://hdl.handle.net/2263/9451
dc.language.iso en en_US
dc.publisher Springer en_US
dc.rights Springer. The original publication is available at www.springerlink.com en_US
dc.subject MHC recognition en_US
dc.subject NK cells en_US
dc.subject T cells en_US
dc.subject Immunoevasins en_US
dc.subject X-ray crystallography en_US
dc.subject MHC-Iv molecules en_US
dc.subject Cytomegalovirus en_US
dc.subject.lcsh Cytomegalovirus infections
dc.subject.lcsh Major histocompatibility complex
dc.subject.lcsh Killer cells
dc.subject.lcsh T cells
dc.subject.lcsh X-ray crystallography
dc.subject.mesh Killer Cells, Natural
dc.title Structure and function of murine cytomegalovirus MHC-I-like molecules : how the virus turned the host defense to its advantage en_US
dc.type Postprint Article en_US


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