Structure and function of murine cytomegalovirus MHC-I-like molecules : how the virus turned the host defense to its advantage

dc.contributor.authorMans, Janet
dc.contributor.authorZhi, Li
dc.contributor.authorRevilleza, Maria Jamela R.
dc.contributor.authorSmith, Lee
dc.contributor.authorRedwood, Alec
dc.contributor.authorNatarajan, Kannan
dc.contributor.authorMargulies, David H.
dc.date.accessioned2009-04-03T11:51:35Z
dc.date.available2009-04-03T11:51:35Z
dc.date.issued2009
dc.description.abstractThe mouse cytomegalovirus (CMV), a β-herpesvirus, exploits its large (~230 kb) double-stranded DNA genome for both essential and non-essential functions. Among the non-essential functions are those that offer the virus a selective advantage in eluding both the innate and adaptive immune responses of the host. Several non-essential genes of MCMV are thought to encode MHC-I-like genes and to function as immunoevasins. To understand further the evolution and function of these viral MHC-I (MHC-Iv) molecules, X-ray structures of several of them have been determined, not only confirming the overall MHC-I-like structure, but also elucidating features unique to this family. Future efforts promise to clarify the nature of the molecular ligands of these molecules, their evolution in the context of the adapting immune response of the murine host, and by analogy the evolution of the host response to human CMV as well. This review is based in part on a Doctoral Dissertation submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa, for the degree of Doctor of Philosophy by Janet Mans [1].en_US
dc.identifier.citationMans, J, Zhi, L, Revilleza, MJR, Smith, L, Redwood, A, Natarajan, K & Margulies, DH 2009, ‘Structure and function of murine cytomegalovirus MHC-I-like molecules : how the virus turned the host defense to its advantage’, Immunologic Research, vol. 43, no. 1-3, pp. 264-279. [http://www.springerlink.com/content/120562/]en_US
dc.identifier.issn0257-277X
dc.identifier.other10.1007/s12026-008-8081-6
dc.identifier.urihttp://hdl.handle.net/2263/9451
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.rightsSpringer. The original publication is available at www.springerlink.comen_US
dc.subjectMHC recognitionen_US
dc.subjectNK cellsen_US
dc.subjectT cellsen_US
dc.subjectImmunoevasinsen_US
dc.subjectX-ray crystallographyen_US
dc.subjectMHC-Iv moleculesen_US
dc.subjectCytomegalovirusen_US
dc.subject.lcshCytomegalovirus infections
dc.subject.lcshMajor histocompatibility complex (MHC)
dc.subject.lcshKiller cells
dc.subject.lcshT cells
dc.subject.lcshX-ray crystallography
dc.subject.meshKiller Cells, Natural
dc.titleStructure and function of murine cytomegalovirus MHC-I-like molecules : how the virus turned the host defense to its advantageen_US
dc.typePostprint Articleen_US

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