dc.contributor.author |
Asiedu, Bernice
|
|
dc.contributor.author |
Lembede, Busisani Wiseman
|
|
dc.contributor.author |
Nyakudya, Trevor Tapiwa
|
|
dc.contributor.author |
Chivandi, Eliton
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|
dc.date.accessioned |
2023-07-12T11:11:05Z |
|
dc.date.available |
2023-07-12T11:11:05Z |
|
dc.date.issued |
2023 |
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dc.description |
DATA AVAILABILITY STATEMENT : Researchers may request data from the authors. Additional data is provided. |
en_US |
dc.description.abstract |
Neonatal alcohol exposure (NAE) can induce oxidative stress. We determined whether zingerone (ZO), a phytochemical with anti-oxidant activity, can mitigate the negative impact of neonatal alcohol-induced oxidative stress. Seventy ten-day-old Sprague-Dawley rat pups (35 male, 35 female) were randomly assigned and administered the following treatment regimens daily from postnatal day (PND) 12–21: group 1 – nutritive milk (NM), group 2 – NM +1 g/kg ethanol (Eth), group 3 – NM + 40 mg/kg ZO, group 4 – NM + Eth + ZO. Growth performance, blood glucose and plasma triglycerides (TGs), total cholesterol, HDL-cholesterol, leptin and insulin concentration were determined. Cytochrome p450E21(CYP2E1) and thiobarbituric acid (TBARS); markers of hepatic oxidative stress and catalase, superoxide dismutase (SOD) and total glutathione (GSH), anti-oxidant markers of the pups were determined. Oral administration of ethanol (NM + Eth), zingerone (NM + ZO) and combined ethanol and zingerone (NM + Eth + ZO) did not affect the growth performance and insulin and leptin concentration of the rats (p > 0.05). Ethanol significantly reduced plasma TGs concentration of female rats (p = 0.04 vs control). However, ethanol and/or its combination with zingerone decreased hepatic GSH (p = 0.02 vs control) and increased CYP2E1 (p = 0.0002 vs control) activity in male rat pups. Zingerone had no effect (p > 0.05 vs control) on the rats' CYP2E1, GSH, SOD and catalase activities. Neonatal alcohol administration elicited hepatic oxidative stress in male rat pups only, showing sexual dimorphism. Zingerone (NM + ZO) prevented an increase in CYP2E1 activity and a decrease in GSH concentration but did not prevent the alcohol-induced hepatic oxidative stress in the male rat pups. |
en_US |
dc.description.department |
Physiology |
en_US |
dc.description.librarian |
hj2023 |
en_US |
dc.description.sponsorship |
The National Research Foundation (NRF) Thuthuka Fund and the Faculty of Health Sciences Research Committee Grant. |
en_US |
dc.description.uri |
https://www.tandfonline.com/journals/idct20 |
en_US |
dc.identifier.citation |
Asiedu, B., Lembede, B.W., Nyakudya, T.T. & Chivandi, E. 2023, 'Orally administered zingerone does not mitigate alcohol-induced hepatic oxidative stress in growing Sprague Dawley rat pups', Drug and Chemical Toxicology, vol. 46, no. 4, pp. 736-745, doi : 10.1080/01480545.2022.2085740. |
en_US |
dc.identifier.issn |
0148-0545 (print) |
|
dc.identifier.issn |
1525-6014 (online) |
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dc.identifier.other |
10.1080/01480545.2022.2085740 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/91371 |
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dc.language.iso |
en |
en_US |
dc.publisher |
Taylor and Francis |
en_US |
dc.rights |
© 2022 Taylor & Francis. This is an electronic version of an article published in Drug and Chemical Toxicology, vol. 46, no. 4, pp. 736-745, 2023. doi : 10.1080/01480545.2022.2085740. Drug and Chemical Toxicology is available online at : https://www.tandfonline.com/journals/idct20. |
en_US |
dc.subject |
Neonatal alcohol exposure (NAE) |
en_US |
dc.subject |
Oxidative stress |
en_US |
dc.subject |
Zingerone |
en_US |
dc.subject |
Alcohol use |
en_US |
dc.subject |
Rat pups |
en_US |
dc.subject |
SDG-03: Good health and well-being |
en_US |
dc.title |
Orally administered zingerone does not mitigate alcohol-induced hepatic oxidative stress in growing Sprague Dawley rat pups |
en_US |
dc.type |
Postprint Article |
en_US |