dc.contributor.author |
Mazur, Natalie I.
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dc.contributor.author |
Lowensteyn, Yvette N.
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dc.contributor.author |
Willemsen, Joukje E.
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dc.contributor.author |
Gill, Christopher J.
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dc.contributor.author |
Forman, Leah
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dc.contributor.author |
Mwananyanda, Lawrence M.
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dc.contributor.author |
Blau, Dianna M.
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dc.contributor.author |
Breiman, Robert F.
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dc.contributor.author |
Madhi, Shabir A.
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dc.contributor.author |
Mahtab, Sana
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dc.contributor.author |
Gurley, Emily S.
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dc.contributor.author |
El Arifeen, Shams
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dc.contributor.author |
Assefa, Nega
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dc.contributor.author |
Scott, J. Anthony G.
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dc.contributor.author |
Onyango, Dickens
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dc.contributor.author |
Barr, Beth A. Tippet
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dc.contributor.author |
Kotloff, Karen L.
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|
dc.contributor.author |
Sow, Samba O.
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dc.contributor.author |
Mandomando, Inacio
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dc.contributor.author |
Ogbuanu, Ikechukwu
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dc.contributor.author |
Jambai, Amara
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dc.contributor.author |
Bassat, Quique
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dc.contributor.author |
CHAMPS Network the RSV GOLD Study Groupa
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dc.contributor.author |
Caballero, Mauricio T.
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dc.contributor.author |
Polack, Fernando P.
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dc.contributor.author |
Omer, Saad
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dc.contributor.author |
Kazi, Abdul Momin
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dc.contributor.author |
Simoes, Eric A.F.
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dc.contributor.author |
Satav, Ashish
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dc.contributor.author |
Bont, Louis J.
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dc.contributor.author |
Venter, Marietjie
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dc.date.accessioned |
2023-02-02T12:38:24Z |
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dc.date.available |
2023-02-02T12:38:24Z |
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dc.date.issued |
2021-09 |
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dc.description.abstract |
BACKGROUND : Respiratory syncytial virus (RSV) is a leading cause of pediatric death, with >99% of mortality occurring in low and lower middle-income countries. At least half of RSV-related deaths are estimated to occur in the community, but clinical characteristics of this group of children remain poorly characterized. METHODS : The RSV Global Online Mortality Database (RSV GOLD), a global registry of under-5 children who have died with RSV-related illness, describes clinical characteristics of children dying of RSV through global data sharing. RSV GOLD acts as a collaborative platform for global deaths, including community mortality studies described in this supplement. We aimed to compare the age distribution of infant deaths <6 months occurring in the community with in-hospital. RESULTS : We studied 829 RSV-related deaths <1 year of age from 38 developing countries, including 166 community deaths from 12 countries. There were 629 deaths that occurred <6 months, of which 156 (25%) occurred in the community. Among infants who died before 6 months of age, median age at death in the community (1.5 months; IQR: 0.8−3.3) was lower than in-hospital (2.4 months; IQR: 1.5−4.0; P < .0001). The proportion of neonatal deaths was higher in the community (29%, 46/156) than in-hospital (12%, 57/473, P < 0.0001). CONCLUSIONS : We observed that children in the community die at a younger age. We expect that maternal vaccination or immunoprophylaxis against RSV will have a larger impact on RSV-related mortality in the community than in-hospital. This case series of RSV-related community deaths, made possible through global data sharing, allowed us to assess the potential impact of future RSV vaccines. |
en_US |
dc.description.department |
Medical Virology |
en_US |
dc.description.librarian |
am2023 |
en_US |
dc.description.sponsorship |
The Bill & Melinda Gates Foundation. |
en_US |
dc.identifier.citation |
Mazur, N.I., Lowensteyn, Y.N., Willemsen, J.E. 2021, 'Global respiratory syncytial virus–related infant community deaths', Clinical Infectious Diseases, vol. 73, supp. 3, pp. S229-S237, doi : 10.1093/cid/ciab528. |
en_US |
dc.identifier.issn |
1058-4838 (print) |
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dc.identifier.issn |
1537-6591 (online) |
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dc.identifier.other |
10.1093/cid/ciab528 |
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dc.identifier.uri |
https://repository.up.ac.za/handle/2263/89103 |
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dc.language.iso |
en |
en_US |
dc.publisher |
Oxford University Press |
en_US |
dc.rights |
© The Author(s) 2021. This is an Open Access article distributed under the terms of the Creative Commons
Attribution License. |
en_US |
dc.subject |
Community death |
en_US |
dc.subject |
Respiratory syncytial virus (RSV) |
en_US |
dc.subject |
Lower respiratory tract infections (LRTIs) |
en_US |
dc.subject |
Low- and middle-income countries (LMICs) |
en_US |
dc.subject |
Pediatric death |
en_US |
dc.title |
Global respiratory syncytial virus–related infant community deaths |
en_US |
dc.type |
Article |
en_US |